School of Health, Physical Education, and Leisure Services, University of Northern Iowa, Cedar Falls, IA 50614-0241, USA. :
Menopause. 2010 May-Jun;17(3):594-601. doi: 10.1097/gme.0b013e3181c92134.
One of the multiple health benefits of soy protein or its isoflavones may be their purported favorable effect on body composition. We examined the effect of isoflavones extracted from soy protein on overall and regional body composition, taking into account appetitive hormones as potential mediators, as well as the direct effect on appetitive hormones.
This randomized, double-blind, placebo-controlled multicenter trial included 229 healthy postmenopausal women (age, 45.8-65 y; body mass index, 24.9 +/- 3.0 kg/m) who consumed placebo or soy isoflavone (80 or 120 mg/d) tablets for 12 months. We used intent-to-treat analysis to examine changes in body composition (whole-body lean mass, whole-body fat mass, androidal fat mass, and androidal-to-gynoidal fat mass ratio) and appetitive hormones (insulin, leptin, ghrelin, and adiponectin) in response to treatment.
Repeated-measures analysis of variance indicated that soy isoflavone treatment did not exert a significant effect on body composition measures (P value from 0.36 to 0.79) or appetitive hormone concentrations; the inclusion of covariates in statistical models did not alter these results. Independently of treatment, leptin and ghrelin related inversely to each body composition measure (P values from 0.044 to < or = 0.0001). Adiponectin related inversely to all fat measures (P values from 0.0004 to <0.0001). Time since last menstrual period related directly to all fat measures (P values from 0.06 to 0.0055). Dietary fat contributed to whole-body (P = 0.028) and androidal (P = 0.017) fat mass.
Our findings do not support a favorable effect of soy isoflavone tablets on body composition in healthy postmenopausal women.
大豆蛋白或其异黄酮的诸多健康益处之一可能是它们据称对身体成分有良好影响。我们研究了从大豆蛋白中提取的异黄酮对整体和局部身体成分的影响，同时考虑了食欲激素作为潜在的介质，以及对食欲激素的直接影响。
这项随机、双盲、安慰剂对照的多中心试验纳入了 229 名健康绝经后妇女（年龄 45.8-65 岁；体重指数 24.9 +/- 3.0 kg/m），她们服用安慰剂或大豆异黄酮（80 或 120 mg/d）片剂 12 个月。我们采用意向治疗分析来检测治疗对身体成分（全身瘦体重、全身脂肪量、躯干脂肪量和躯干与骨盆脂肪量比）和食欲激素（胰岛素、瘦素、ghrelin 和脂联素）的变化。
重复测量方差分析表明，大豆异黄酮处理对身体成分测量值（P 值从 0.36 到 0.79）或食欲激素浓度没有显著影响；在统计模型中纳入协变量并没有改变这些结果。独立于治疗，瘦素和 ghrelin 与每个身体成分测量值呈负相关（P 值从 0.044 到 <= 0.0001）。脂联素与所有脂肪测量值呈负相关（P 值从 0.0004 到 <0.0001）。绝经后时间与所有脂肪测量值呈正相关（P 值从 0.06 到 0.0055）。膳食脂肪对全身（P = 0.028）和躯干（P = 0.017）脂肪量有贡献。
我们的发现不支持大豆异黄酮片剂对健康绝经后妇女身体成分的有利影响。
