Shobha N, Taly Arun B, Sinha Sanjib, Venkatesh T
Department of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), India.
Ann Indian Acad Neurol. 2009 Apr;12(2):111-5. doi: 10.4103/0972-2327.53080.
Lead is a ubiquitous and versatile metal that has been used by mankind for many years. It is a toxic heavy metal that ranks as one of the most important environmental poisons in the world. Research conducted in recent years has increased public health concern about the toxicity of lead at low doses and has supported a reappraisal of the levels of lead exposure that may be safely tolerated in the workplace. Neuropathy is one complication of lead poisoning. The aim of this study is to describe the phenotypic and electrophysiological profile in five male patients working in a battery factory who developed radial nerve neuropathy due to lead exposure. All patients had elevated blood lead levels that were in the toxic range. The concerned regulatory bodies should make it mandatory for workers to undergo regular health checkups to detect signs of lead poisoning and must ensure that workers are aware about the ill effects of exposure to this metal. Chelation therapy removes lead from the blood and soft tissues and chronic lead exposure often requires repeated courses of treatment.
铅是一种广泛存在且用途多样的金属,人类使用它已有多年。它是一种有毒重金属,位列世界上最重要的环境毒物之一。近年来开展的研究增加了公众对低剂量铅毒性的健康担忧,并支持重新评估工作场所可安全耐受的铅暴露水平。神经病变是铅中毒的一种并发症。本研究的目的是描述五名在电池厂工作、因铅暴露而发生桡神经病变的男性患者的表型和电生理特征。所有患者的血铅水平均升高至中毒范围。相关监管机构应强制要求工人定期进行健康检查以检测铅中毒迹象,并且必须确保工人了解接触这种金属的不良影响。螯合疗法可从血液和软组织中清除铅,而慢性铅暴露通常需要重复疗程的治疗。