Chowdhary Aarti, Gayathri G V, Mehta Dhoom Singh
Former Post graduate Student, Department of Periodontology and Implantology, Bapuji Dental College and Hospital, Davanagere - 577 004, Karnataka, India.
J Indian Soc Periodontol. 2008 Jan;12(1):16-20. doi: 10.4103/0972-124X.44092.
Recent evidences prove that, release of potent lysosomal enzymes e.g. beta-Glucuronidase by degranulation of polymorponuclear leukocytes in host gingiva may contribute significantly to tissue destruction and the pathogenesis of periodontal disease. The purpose of the present study was to compare and correlate GCF beta-Glucuronidase with periodontal status among diabetic and non-diabetic patients with chronic periodontitis. A total number of 75 patients were equally divided into Group I (control group), Group II (non diabetic with chronic periodontitis) and Group III (diabetic with chronic periodontitis). Clinical parameters like Plaque index, Gingival index, Probing Pocket Depth and RBS were recorded. The beta-Glucuronidase level in GCF of all three groups was determined by spectrophotometric analysis. It was observed that the periodontitis patients irrespective of their diabetic status, showed increased periodontal destruction with elevated level of beta-Glucuronidase than the controls. Also, the diabetic patients showed increased severity of periodontal destruction and the elevated level of beta-Glucuronidase, thus indicating diabetics at a higher risk for progressive periodontal destruction.
最近的证据表明，宿主牙龈中的多形核白细胞脱颗粒释放强效溶酶体酶，如β-葡萄糖醛酸酶，可能在很大程度上导致组织破坏和牙周病的发病机制。本研究的目的是比较并关联慢性牙周炎糖尿病患者和非糖尿病患者龈沟液中β-葡萄糖醛酸酶与牙周状况。总共75名患者被平均分为第一组（对照组）、第二组（非糖尿病慢性牙周炎患者）和第三组（糖尿病慢性牙周炎患者）。记录了菌斑指数、牙龈指数、探诊深度和随机血糖等临床参数。通过分光光度分析测定了三组龈沟液中β-葡萄糖醛酸酶水平。观察到，无论糖尿病状态如何，牙周炎患者均表现出比对照组更严重的牙周组织破坏，且β-葡萄糖醛酸酶水平升高。此外，糖尿病患者的牙周破坏程度更高，β-葡萄糖醛酸酶水平也更高，这表明糖尿病患者发生进行性牙周破坏的风险更高。
