Mohamed Maha M
Department of Ophthalmology, Faculty of Medicine, kasr el Aini Hospital, Cairo University.
Middle East Afr J Ophthalmol. 2009 Jul;16(3):141-5. doi: 10.4103/0974-9233.56228.
To detect early glaucomatous changes in pseudo exfoliative patients with normal intraocular pressure (IOP), visual field and optic nerve head appearance; by measuring retinal nerve fiber layer (RNFL) thickness using optical coherence tomography (OCT).
A prospective observational case-control study.
Twenty non-glaucomatous (normal IOP, fundus and visual field) pseudo exfoliative patients and 20 age matched healthy control subjects.
The RNFL thickness (global and four quadrants) was assessed using combined imaging system OTI (OCT/SLO) and compared with age matched normal control subjects.
The RNFL in patients with pseudo exfoliation syndrome (PXS) was significantly thinner in all quadrants except the nasal quadrant compared to the control group (p less than 0.05).
Measurement of RNFL thickness by OCT is useful in detecting early RNFL damage which in turn provides clinically relevant information in detecting early glaucomatous changes in pseudo exfoliative patients.
通过光学相干断层扫描（OCT）测量视网膜神经纤维层（RNFL）厚度，以检测眼压（IOP）、视野和视神经乳头外观正常的假性剥脱性患者的早期青光眼性改变。
一项前瞻性观察性病例对照研究。
20名非青光眼性（眼压、眼底和视野正常）假性剥脱性患者和20名年龄匹配的健康对照者。
使用联合成像系统OTI（OCT/SLO）评估RNFL厚度（整体和四个象限），并与年龄匹配的正常对照者进行比较。
与对照组相比，假性剥脱综合征（PXS）患者除鼻侧象限外，所有象限的RNFL均明显变薄（p<0.05）。
通过OCT测量RNFL厚度有助于检测早期RNFL损伤，进而为检测假性剥脱性患者的早期青光眼性改变提供临床相关信息。
