Yasmeen Naila, Fatima Nauroz
Dr. Naila Yasmeen, FCPS. Armed Forces Institute of Ophthalmology, Rawalpindi, Pakistan.
Dr. Nauroz Fatima, FCPS. Combined Military Hospital, Rawalpindi, Pakistan.
Pak J Med Sci. 2016 Nov-Dec;32(6):1533-1536. doi: 10.12669/pjms.326.11075.
To compare mean retinal nerve fiber layer (RNFL) thickness in patients having pseudo exfoliation (PXF) with normal age matched controls using spectral domain optical coherence tomography (SD-OCT).
This was a case control study conducted at Armed Forces Institute of Ophthalmology (AFIO) Rawalpindi from 12 June 2013 to 12 January 2014. Seventy eyes (Group A - 35 patients with PXF and Group B - 35 healthy age matched subjects) of more than 40 years of age were included in the study. Intraocular pressure (IOP) was measured with Goldmann applanation tonometer (GAT) and peripapillary RNFL thickness was measured in four quadrants with SD-OCT (Topcon 3D OCT-1000 Mark II) in all subjects. Data was analyzed using the SPSS version 14.
Mean age of group A (PXF patients) was 65.63 ± 8.47 years and of group B (Healthy subjects) was 64.31 ± 6.51 years (p = 0.470). Both groups were gender matched with male preponderance (p = 0.673). Mean IOP in each group was 13.80 ± 2.59 mm Hg, and 13.49 ± 2.07 mm Hg respectively (p= 0.578). Mean average peripapillary RNFL thickness was 77.46 ± 12.17 µm in group A and 83.96 ± 10.58 µm in group B. Statistically significant differences were detected between two groups for mean average RNFL thickness (p= 0.020) and mean RNFL thickness in inferior quadrant (p=0.014).
PXF patients with normal IOP and visual fields have thin RNFL as compared to healthy age matched controls. Therefore routine assessment and follow up of PXF patients with OCT may help in early diagnosis of PXF glaucoma.
使用光谱域光学相干断层扫描（SD-OCT）比较假性剥脱（PXF）患者与年龄匹配的正常对照者的平均视网膜神经纤维层（RNFL）厚度。
这是一项于2013年6月12日至2014年1月12日在拉瓦尔品第武装部队眼科研究所（AFIO）进行的病例对照研究。研究纳入了70只年龄超过40岁的眼睛（A组 - 35例PXF患者和B组 - 35名年龄匹配的健康受试者）。所有受试者均使用Goldmann压平眼压计（GAT）测量眼压，并使用SD-OCT（Topcon 3D OCT-1000 Mark II）在四个象限测量视乳头周围RNFL厚度。使用SPSS 14版分析数据。
A组（PXF患者）的平均年龄为65.63±8.47岁，B组（健康受试者）的平均年龄为64.31±6.51岁（p = 0.470）。两组性别匹配，男性占优势（p = 0.673）。每组的平均眼压分别为13.80±2.59 mmHg和13.49±2.07 mmHg（p = 0.578）。A组视乳头周围RNFL平均厚度为77.46±12.17 µm，B组为83.96±10.58 µm。两组之间在平均RNFL厚度（p = 0.020）和下象限平均RNFL厚度（p = 0.014）方面检测到统计学上的显著差异。
与年龄匹配的健康对照者相比，眼压和视野正常的PXF患者的RNFL较薄。因此，对PXF患者进行OCT常规评估和随访可能有助于PXF青光眼的早期诊断。
