新西兰白兔直肠阴道瘘修复术中的间置移植术
Interposition grafts for rectovaginal fistula repair in the New Zealand white rabbit.
作者信息
Aungst Matthew J, Bearss Jeremy J, Lewis Bridget S, Fischer John R, Bonhage Michael R, Wright Johnnie
机构信息
Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Obstetrics and Gynecology, Walter Reed Army Medical Center, Bldg 2, Rm 2J06, 6900 Georgia Avenue, Washington, DC 20307, USA.
出版信息
Int Urogynecol J. 2010 Jun;21(6):737-42. doi: 10.1007/s00192-010-1096-2. Epub 2010 Feb 9.
INTRODUCTION AND HYPOTHESIS
The objective was to use an animal model to study different types of interposition grafts for rectovaginal fistula repair.
METHODS
Twelve New Zealand white rabbits underwent surgical creation of a rectovaginal fistula, followed by repair. Four repair techniques were studied; three with interposition grafts and one control group without a graft. Animals were euthanized at 4-week intervals and underwent gross and histologic analysis.
RESULTS
The mean rectovaginal wall thickness was greatest in the control group (5.6 mm) and thinnest in the autologous rectus fascia (4.2 mm) and porcine small intestine submucosa (5.1 mm) groups. The polypropylene graft had a mean thickness of 5.4 mm and elicited a strong, protracted inflammatory response. All fistulas were successfully closed except one porcine small intestine submucosa repair.
CONCLUSIONS
There is no benefit from interposition graft use for rectovaginal fistula repair in our New Zealand white rabbit model.
引言与假设
目的是使用动物模型研究用于直肠阴道瘘修复的不同类型的间置移植物。
方法
12只新西兰白兔接受了直肠阴道瘘的手术造瘘，随后进行修复。研究了四种修复技术；三种使用间置移植物，一个对照组不使用移植物。每隔4周对动物实施安乐死，并进行大体和组织学分析。
结果
对照组的直肠阴道壁平均厚度最大（5.6毫米），自体腹直肌筋膜组（4.2毫米）和猪小肠黏膜下层组（5.1毫米）最薄。聚丙烯移植物的平均厚度为5.4毫米，并引发强烈、持久的炎症反应。除一例猪小肠黏膜下层修复外，所有瘘管均成功闭合。
结论
在我们的新西兰白兔模型中，间置移植物用于直肠阴道瘘修复并无益处。
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