Pierce Lisa M, Grunlan Melissa A, Hou Yaping, Baumann Shannon S, Kuehl Thomas J, Muir Tristi W
Department of Obstetrics and Gynecology, Scott & White Memorial Hospital and Clinic, Texas A&M University Health Science Center College of Medicine, Temple, TX, USA.
Am J Obstet Gynecol. 2009 May;200(5):549.e1-8. doi: 10.1016/j.ajog.2008.12.041. Epub 2009 Mar 14.
We sought to evaluate the effects of anatomic location and ovariectomy on biomechanical properties of synthetic and biologic graft materials after long-term implantation.
A total of 35 rabbits underwent ovariectomy or sham laparotomy and were implanted with polypropylene (PP) mesh (n = 17) or cross-linked porcine dermis (PS) (n = 18) in the vagina and abdomen. Grafts were harvested 9 months later and underwent mechanical properties testing.
After implantation, PS was similar in strength (P = .52) but was twice as stiff as PP (P = .04) and had a maximal elongation only half that of PP (P < .001). Degradation of PS was associated with decreased ultimate tensile strength (P = .03) and elastic modulus (P = .046). Vaginal PP grafts shrunk more (P < .001) and were less stiff than abdominal PP grafts (P = .049) but were not different in strength (P = .19). Ovariectomy had no effect (P > .05).
Cross-linked PS undergoes long-term degradation resulting in compromised biomechanical properties and thus is likely inferior to lightweight PP meshes for pelvic organ prolapse and incontinence procedures.
我们试图评估解剖位置和卵巢切除术对长期植入后合成和生物移植材料生物力学特性的影响。
总共35只兔子接受了卵巢切除术或假剖腹手术，并在阴道和腹部植入聚丙烯（PP）网片（n = 17）或交联猪真皮（PS）（n = 18）。9个月后取出移植物并进行力学性能测试。
植入后，PS的强度相似（P = 0.52），但刚度是PP的两倍（P = 0.04），最大伸长率仅为PP的一半（P < 0.001）。PS的降解与极限抗拉强度降低（P = 0.03）和弹性模量降低（P = 0.046）有关。阴道PP移植物收缩更多（P < 0.001），刚度低于腹部PP移植物（P = 0.049），但强度无差异（P = 0.19）。卵巢切除术无影响（P > 0.05）。
交联PS会长期降解，导致生物力学性能受损，因此在盆腔器官脱垂和尿失禁手术中可能不如轻质PP网片。
