新西兰白兔直肠阴道瘘模型
Rectovaginal fistula model in the New Zealand white rabbit.
作者信息
Aungst Matthew J, Fischer John R, Bonhage Michael R, Albright Todd S, Noel Kathleen A, Wright Johnnie
机构信息
Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Obstetrics and Gynecology, Walter Reed Army Medical Center, Washington, DC, USA.
出版信息
Int Urogynecol J. 2010 Jul;21(7):885-8. doi: 10.1007/s00192-010-1118-0. Epub 2010 Feb 26.
INTRODUCTION AND HYPOTHESIS
The purpose of this study was to create an animal model to study rectovaginal fistula repair.
METHODS
Fourteen New Zealand white rabbits underwent surgical creation of a rectovaginal fistula. The technique was developed with a pilot study conducted on the first two animals, then standardized and performed on the remaining 12 rabbits. The standardized technique included making a defect in the rectovaginal septum using a 3-mm skin punch then splinting the defect with 6-mm tubing for 2 weeks.
RESULTS
Using the standardized technique, a fistula was successfully created in all 12 rabbits ranging from 1 to 5 mm (mean = 2.8 mm, SD = 1.1). A 95% tolerance interval was calculated for the model and predicted that a successful fistula can be created ranging from 0.3 to 5.2 mm in 85% of attempts with the model.
CONCLUSION
The New Zealand white rabbit is a promising animal model to study rectovaginal fistula repair.
引言与假设
本研究的目的是创建一个用于研究直肠阴道瘘修复的动物模型。
方法
对14只新西兰白兔进行了直肠阴道瘘的手术造模。该技术在前两只动物上进行了初步研究后得以发展，然后进行标准化并应用于其余12只兔子。标准化技术包括使用3毫米皮肤打孔器在直肠阴道隔上制造缺损，然后用6毫米的导管对缺损进行支撑固定2周。
结果
采用标准化技术，在所有12只兔子中均成功制造出瘘管，瘘管大小在1至5毫米之间（平均 = 2.8毫米，标准差 = 1.1）。为该模型计算了95%的耐受区间，并预测使用该模型在85%的尝试中可成功制造出大小在0.3至5.2毫米之间的瘘管。
结论
新西兰白兔是一种有前景的用于研究直肠阴道瘘修复的动物模型。
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