Nencki Institute of Experimental Biology, 3 Pasteur Street, 02-093, Warsaw, Poland.
Neurochem Res. 2010 May;35(5):743-8. doi: 10.1007/s11064-010-0131-5. Epub 2010 Feb 9.
Neurons are known to accumulate L-carnitine--a compound necessary for transfer of acyl moieties through biological membranes, apart from very low beta-oxidation of fatty acids in adult brain. Present study demonstrates expression of octn2 and octn3 genes coding high affinity carnitine transporters, as well as presence of both proteins in neurons obtained from suckling and adult rats, and also in mouse transformed neural cells. Measurements of carnitine transport show activity of both transporters in neural cells, pointing to their importance in physiological processes other than beta-oxidation.
神经元被认为会积累 L-肉碱——一种穿过生物膜转移酰基部分所必需的化合物，除了成年大脑中极低的脂肪酸β氧化。本研究表明，编码高亲和力肉碱转运体的 octn2 和 octn3 基因表达，以及从哺乳期和成年大鼠获得的神经元中这两种蛋白质的存在，以及在小鼠转化的神经细胞中也存在。肉碱转运的测量显示两种转运体在神经细胞中的活性，表明它们在β氧化以外的生理过程中的重要性。
