氯取代扁桃酸和苯乙胺非对映异构体盐的手性识别。

Chiral discrimination in diastereomeric salts of chlorine-substituted mandelic acid and phenylethylamine.

机构信息

Department of Chemical and Biochemical Engineering, the University of Western Ontario London, Ontario, Canada.

出版信息

Chirality. 2010 Aug;22(8):707-16. doi: 10.1002/chir.20822.

DOI:10.1002/chir.20822

PMID:20143411

Abstract

The crystal structures of diastereomeric salts of chloromandelic acid and phenylethylamine were determined and are presented herein. The structure comparison between less soluble salts and more soluble salts shows that weak interactions such as CH/pi interactions and van der Waals gain importance and contribute to chiral recognition when the hydrogen bonding patterns are very similar.

摘要

本文报道了氯缬草酸和苯乙胺非对映异构体盐的晶体结构。对溶解度较低的盐和溶解度较高的盐的结构比较表明，当氢键模式非常相似时，CH/pi 相互作用和范德华力等弱相互作用变得重要，并有助于手性识别。