Department of Psychology, University of California Los Angeles, Los Angeles, California, USA.
Depress Anxiety. 2010 Apr;27(4):404-11. doi: 10.1002/da.20645.
This study is aimed to evaluate the role of two vulnerability factors, health anxiety and fear of fear, in the prediction of the onset of panic disorder/agoraphobia (PDA) relative to a comparison anxiety disorder.
Young women, aged between 18 and 24 years, were investigated at baseline and, 17 months later, using the Anxiety Disorders Interview Schedule-Lifetime and measures of health anxiety and fear of bodily sensations (subscale disease phobia of the Whiteley Index, and total score of the Body Sensations Questionnaire). First, 22 women with current PDA were compared to 81 women with current social phobia and 1,283 controls. Second, 24 women with an incidence of PDA were compared to 60 women with an incidence of social phobia and 1,036 controls.
Multiple logistic regression analyses adjusted for history of physical diseases, somatic symptoms, and other psychological disorders revealed that (a) fear of bodily sensations was elevated for women with PDA vs. controls as well as women with social phobia, and (b) health anxiety (and history of physical diseases) was elevated in women who developed PDA vs. controls and vs. women who developed social phobia.
These results suggest that health anxiety, as well as history of physical diseases, may be specific vulnerability factors for the onset of PDA relative to social phobia. Whereas fear of bodily sensations was not found to be a risk factor for the onset of panic disorder/agoraphobia, it was a specific marker of existing PDA relative to social phobia.
本研究旨在评估健康焦虑和恐惧恐惧这两个脆弱性因素在预测惊恐障碍/广场恐惧症（PDA）发病方面相对于比较焦虑障碍的作用。
对年龄在 18 至 24 岁之间的年轻女性进行基线调查，并在 17 个月后使用焦虑障碍访谈时间表-终身和健康焦虑以及躯体感觉恐惧（怀特利指数疾病恐惧症量表和身体感觉问卷总分）进行测量。首先，将 22 名当前患有 PDA 的女性与 81 名当前患有社交恐惧症的女性和 1283 名对照者进行比较。其次，将 24 名发生 PDA 的女性与 60 名发生社交恐惧症的女性和 1036 名对照者进行比较。
调整了既往躯体疾病、躯体症状和其他心理障碍史的多变量逻辑回归分析显示，（a）与对照组和社交恐惧症组相比，患有 PDA 的女性对躯体感觉的恐惧程度升高，（b）患有 PDA 的女性与对照组相比，健康焦虑（和既往躯体疾病）升高，与发生社交恐惧症的女性相比，健康焦虑（和既往躯体疾病）升高。
这些结果表明，健康焦虑以及既往躯体疾病可能是相对于社交恐惧症发生 PDA 的特定脆弱性因素。虽然躯体感觉恐惧不是惊恐障碍/广场恐惧症发病的危险因素，但它是相对于社交恐惧症存在 PDA 的特定标志物。
