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[使用肠吸附剂治疗急性乙醇中毒的实验原理]

[Experimental rationale for the use of enterosorbents in acute ethanol intoxication].

作者信息

Orbidans A G, Terekhin G A, Vladimirskiĭ E V, Terekhina N A

出版信息

Patol Fiziol Eksp Ter. 2009 Oct-Dec(4):29-30.

Abstract

The experiment on 83 rats has provided a rationale for the use of enterosorbents in acute ethanol intoxication. Polysorb reduces the halflife of ethanol, recovers physical fitness in the animals with acute poisoning. The enterosorbents polysorb, litovit, and sapropel have been found to have a corrective effect on the level of the major plasma antioxidant ceruloplasmin in acute ethanol intoxication. Enterosorbents are an effective detoxifying agent in this condition. Examining the mechanisms of toxic action of ethanol allows the most expedient treatment policy to be substantiated in acute poisonings.

摘要

对83只大鼠进行的实验为在急性乙醇中毒中使用肠吸附剂提供了理论依据。聚山梨醇酯可缩短乙醇的半衰期,使急性中毒动物恢复体能。已发现肠吸附剂聚山梨醇酯、立托维特和腐殖泥对急性乙醇中毒时主要血浆抗氧化剂铜蓝蛋白水平具有校正作用。在这种情况下,肠吸附剂是一种有效的解毒剂。研究乙醇的毒性作用机制有助于在急性中毒时确定最适宜的治疗策略。

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