Gorodkov A Iu, Kostava V T, Fadeev A A
Vestn Ross Akad Med Nauk. 2009(12):9-16.
Blood flow in heart and main vessels is a self-organizing eddy flow described by Kiknadze-Krasnov's non-stationary hydrodynamic equations. Their exact solutions are applicable to simulation of blood circulation in normal and pathological conditions, quantitative evaluation of efficiency of surgical treatment of cardiovascular diseases, and designing implantable devices for cardiovascular surgery to support physiological blood flow structure. An essentially new all-flow three-leaflet CorBit artificial heart valve from pyrolyitic carbon has been proposed to maintain physiological blood flow with minimal regurgitation and transvalvular pressure gradient. The CorBit valve allows to normalize hemodynamic parameters soon after implantation. Also, manufacture is underway of a wide range of original stented and stentless bioprostheses of heart valves and valve-containing BioLab conduits from allogenic and xenogenic biological tissues. BioLab bioprostheses are currently widely used to treat complicated congenital and acquired forms of cardiopathology.
心脏和主要血管中的血流是一种自组织涡流，可用基克纳泽-克拉斯诺夫的非定常流体动力学方程来描述。其精确解适用于正常和病理条件下的血液循环模拟、心血管疾病外科治疗效果的定量评估，以及设计用于心血管手术的可植入装置以支持生理血流结构。已提出一种全新的由热解碳制成的全流式三叶CorBit人工心脏瓣膜，以维持生理血流，使反流和跨瓣压力梯度最小化。CorBit瓣膜可在植入后不久使血液动力学参数正常化。此外，正在制造一系列由同种异体和异种生物组织制成的心脏瓣膜及含瓣膜的BioLab导管的原创带支架和无支架生物假体。BioLab生物假体目前广泛用于治疗复杂的先天性和后天性心脏病形式。
