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[切尔诺贝利事故后果清理者后代中的先天性畸形]

[Congenital malformations among offspring of the liquidators of the consequences from Chernobyl accident].

作者信息

Liaginskaia A M, Tukov A R, Osipov V A, Ermalitskiĭ A P, Prokhorova O N

出版信息

Radiats Biol Radioecol. 2009 Nov-Dec;49(6):694-702.

Abstract

The frequency and the structure of congenital malformations at children of the liquidators of the consequences from Chernobyl accident, undergone to an external scale gamma-irradiation in dozes up to 25 cGy. In total is surveyed 2379 newborn at which is revealed 318 intrauterine development defects. The received results are compared to the earlier published data on birth of congenital malformations in families of the fathers who have undergone to an irradiation in connection with professional activity at the enterprises of a nuclear industry, with emergency irradiation, with irradiation as a result of explosions of nuclear bombs in Japan, and are discussed from positions of the basic rules (situations) of radiating genetics. Total frequency, the frequency of forms 21 of inherent defects of development, taken into account in the International register of congenital malformations and frequency 9 forms heaviest of congenital intrauterine development defects with the high contribution mutation components at children of the liquidators authentically is higher than on the average on Russian Federation. The dependence of the frequency congenital malformations at children from dozes of an irradiation of the fathers--liquidators is revealed. The curve of dependence of the frequency of congenital malformations from time, past after work up to copulation carries arched character with peak of rise of frequency of congenital malformations in 2-3 years and decrease in 6-7 years.

摘要

切尔诺贝利事故后果清理者的子女中先天性畸形的发生率及结构,这些清理者曾接受剂量高达25厘戈瑞的外照射伽马辐射。总共调查了2379名新生儿,其中发现318例宫内发育缺陷。将所得结果与先前发表的关于在核工业企业因职业活动接受辐射的父亲家庭、因紧急辐射、因日本原子弹爆炸而接受辐射的父亲家庭中先天性畸形出生情况的数据进行比较,并从辐射遗传学的基本规则(情况)角度进行讨论。在切尔诺贝利事故清理者子女中,先天性畸形的总发生率、国际先天性畸形登记册中记录的21种固有发育缺陷形式的发生率以及9种最严重的先天性宫内发育缺陷形式(其突变成分贡献较高)的发生率确实高于俄罗斯联邦的平均水平。揭示了切尔诺贝利事故清理者子女先天性畸形发生率与父亲辐射剂量之间的关系。先天性畸形发生率与从工作结束到交配所经过时间的关系曲线呈拱形,先天性畸形发生率在2至3年达到峰值,在6至7年下降。

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