Paquet P, Vandenbossche G, Nikkels A F, Henry F, Piérard G E
Service de Dermatopathologie, CHU de Liège.
Rev Med Liege. 2009 Dec;64(12):601-5.
Iodinated contrast agents are frequently involved in delayed polymorphic adverse skin reactions. Acute generalized exanthematous pustulosis following administration of iodinated contrast agents is a rare but severe form of such reactions. The disease is characterized by the sudden occurrence of an erosive and pustular erythroderma with fever, leukocytosis and sometimes peripheral adenopathies and liver involvement. This condition is considered as an immunologic reaction, primarily involving T lymphocytes. The overall mortality reaches about 1%. Elucidating the differential diagnosis with other acute paroxysmal drug eruptions (toxic epidermal necrolysis, Steven-Johnson syndrome and drug hypersensitivity syndrome) is of paramount importance for establishing the adequate treatment of PEAG.
碘化造影剂常引发迟发性多形性皮肤不良反应。使用碘化造影剂后发生的急性泛发性脓疱性皮病是此类反应中一种罕见但严重的形式。该病的特征为突然出现糜烂性和脓疱性红皮病，并伴有发热、白细胞增多，有时还伴有外周淋巴结肿大和肝脏受累。这种情况被认为是一种免疫反应，主要涉及T淋巴细胞。总体死亡率约为1%。明确与其他急性发作性药疹（中毒性表皮坏死松解症、史蒂文斯-约翰逊综合征和药物超敏反应综合征）的鉴别诊断对于确立急性泛发性脓疱性皮病的恰当治疗至关重要。
