Sholapurkar S L
Department of Obstetrics and Gynaecology, Royal United Hospital, Bath, UK.
J Obstet Gynaecol. 2010 Feb;30(2):107-10. doi: 10.3109/01443610903470288.
Advice given to women regarding optimum interpregnancy interval (IPI) following spontaneous miscarriage remains controversial. There is robust evidence from many studies including a meta-analysis that after full term or pre-term delivery, IPIs of <18 months and >5 years are associated with increased risk of poor perinatal and maternal outcome. However, there is paucity of good studies to infer the effect of IPI after a spontaneous miscarriage, which is a relatively common event. The results have been variable and inconsistent but a recent good quality study (DaVanzo et al. 2007 ) showed similar pregnancy outcome with IPIs of <6, 6-14, 15-26 and 27-50 months following spontaneous miscarriage. Hence, it seems reasonable to attempt conception soon after an uncomplicated miscarriage in otherwise healthy women depending on their desire. More good quality, preferably prospective studies regarding effect IPI after miscarriage are required for better evidence-based advice.
针对自然流产后最佳再次妊娠间隔时间（IPI）给予女性的建议仍存在争议。包括一项荟萃分析在内的许多研究都有确凿证据表明，足月或早产分娩后，IPI小于18个月和大于5年与围产期及孕产妇不良结局风险增加相关。然而，对于自然流产（这是一个相对常见的事件）后IPI的影响，缺乏高质量的研究来进行推断。研究结果各不相同且不一致，但最近一项高质量研究（达万佐等人，2007年）表明，自然流产后IPI小于6个月、6 - 14个月、15 - 26个月和27 - 50个月时，妊娠结局相似。因此，对于其他方面健康的女性，在经历一次无并发症的流产后，根据她们的意愿尽快尝试受孕似乎是合理的。需要更多高质量、最好是前瞻性的关于流产后IPI影响的研究，以便提供更有循证依据的建议。
