Norman Consulting, 18 Pink Lane, Burnham, Buckinghamshire, SL1 8JW, UK.
Expert Opin Ther Pat. 2006 Sep;16(9):1315-20. doi: 10.1517/13543776.16.9.1315.
Two applications claim a novel class of muscarinic M(3) receptor antagonists and their use as long-acting agents for the treatment of chronic obstructive pulmonary disease. The two applications claim closely related structures with one claiming quaternary amine salts of the tertiary amines claimed in the other. The claimed compounds comprise a biarylmethylamine core with the amino group modified by acylation or sulfonation and a tertiary or quaternary amine coupled to the distal ring of the biaryl system.
两项申请声称是一类新型的毒蕈碱 M(3) 受体拮抗剂，可作为长效药物用于治疗慢性阻塞性肺疾病。这两项申请声称的结构密切相关，其中一项申请要求的是另一份申请中所要求的叔胺的季铵盐。所要求的化合物包括联苯甲胺核心，其氨基被酰化或磺化修饰，并且叔胺或季铵与联苯系统的远端环相连。
