Norman Consulting, 18 Pink Lane, Burnham, Buckinghamshire, SL1 8JW, UK.
Expert Opin Ther Pat. 2006 Sep;16(9):1327-31. doi: 10.1517/13543776.16.9.1327.
Bifunctional aromatic derivatives that act as both beta(2) agonists and muscarinic receptor antagonists are claimed. The compounds use two separate pharmacophoric groups, coupled by a long lipohilic chain, to provide the desired biological activities and with the aim of providing a long duration of action. The compounds are claimed to be useful in the treatment of both asthma and chronic obstructive pulmonary disease and represent the first disclosure of a new concept - muscarinic antagonist-beta(2) agonists.
据称，有一种双功能芳香衍生物，它既能作为β2 激动剂，又能作为毒蕈碱受体拮抗剂。这些化合物使用两个独立的药效团，通过一条长的亲脂链连接，以提供所需的生物活性，并旨在提供长效作用。这些化合物据称可用于治疗哮喘和慢性阻塞性肺疾病，代表了一个新概念的首次披露 - 毒蕈碱受体拮抗剂-β2 激动剂。
