Department of Nephrology and Hypertension, Friedrich-Alexander University, Erlangen, Germany.
Clin Exp Hypertens. 2010 Jan;32(1):35-42. doi: 10.3109/10641960902960532.
Most patients with hypertension require two or more agents from different classes to achieve BP control. Several fixed-dose combinations are available, often combining agents that target the renin angiotensin system (angiotensin-converting enzyme [ACE] inhibitors or an angiotensin receptor blockers [ARBs]) plus either thiazide diuretics or calcium channel blockers (CCBs). At low doses, these combinations may have greater efficacy and better tolerability than the respective high dose monotherapies. Combining an ARB (instead of an ACE inhibitor) with the CCB amlodipine offers efficacy with improved tolerability. This review aims to highlight the simplicity, tolerability, and convenience of fixed-dose combinations targeting the renin-angiotensin system, which can lead to improved compliance and more patients achieving BP goals.
大多数高血压患者需要两种或多种来自不同类别的药物来控制血压。有几种固定剂量的组合可供选择，通常将作用于肾素-血管紧张素系统的药物（血管紧张素转换酶 [ACE] 抑制剂或血管紧张素受体阻滞剂 [ARB]）与噻嗪类利尿剂或钙通道阻滞剂 (CCB) 联合使用。在低剂量下，这些组合的疗效可能比各自的高剂量单药治疗更好，耐受性也更好。将 ARB（而非 ACE 抑制剂）与 CCB 氨氯地平联合使用可提高疗效并改善耐受性。本综述旨在强调针对肾素-血管紧张素系统的固定剂量组合的简单性、耐受性和便利性，这可以提高患者的依从性，使更多患者达到血压目标。
