Department of Otorhinolaryngology, Shandong Qianfoshan Hospital, Shandong, PR China.
Clin Exp Hypertens. 2010 Jan;32(1):49-53. doi: 10.3109/10641960902993079.
This study aimed to investigate the value of the surgery of revised uvulopalatopharyngoplasty (UPPP) on ambulatory blood pressure (BP) in obstructive sleep apnea/hypopnea syndrome (OSAHS) patients with hypertension and oropharyngeal obstruction. A retrospective cohort study was performed in 29 patients with OSAHS and hypertension, who received treatment with revised UPPP surgery. After surgery 1 month, the Apnea-hypopna index (AHI) and body mass index (BMI) significantly decreased (P < 0.05), and mini SpO(2) and mean SpO(2) increased than before (P < 0. 05), but the heart rate showed no significant difference (P > 0.05). In the meantime, compared to pretreatment, nighttime systolic SBP, nighttime diastolic DBP, morning systolic SBP, morning diastolic DBP, 24-h DBP, and 24-h SBP, decreased significantly (P < 0.05), but daytime SBP and daytime DBP showed no significant difference (P > 0.05). The results of this study indicated that the BP in the sleep apnea patients with hypertension might gradually decrease by revised UPPP surgery.
本研究旨在探讨修正悬雍垂腭咽成形术（UPPP）治疗伴或不伴口咽阻塞的阻塞性睡眠呼吸暂停低通气综合征（OSAHS）合并高血压患者的动态血压（BP）的价值。回顾性队列研究纳入了 29 例 OSAHS 合并高血压患者，均接受了修正 UPPP 手术治疗。术后 1 个月，呼吸暂停低通气指数（AHI）和体质量指数（BMI）明显降低（P＜0.05），最小血氧饱和度（mini SpO₂）和平均 SpO₂较术前增加（P＜0.05），但心率无明显差异（P＞0.05）。同时，与术前相比，夜间收缩压（SBP）、夜间舒张压（DBP）、晨起 SBP、晨起 DBP、24 h DBP 和 24 h SBP 明显降低（P＜0.05），但日间 SBP 和日间 DBP 无明显差异（P＞0.05）。该研究结果表明，修正 UPPP 手术可能会使睡眠呼吸暂停合并高血压患者的血压逐渐降低。
