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舌根悬吊联合悬雍垂腭咽成形术治疗重度阻塞性睡眠呼吸暂停:长期随访结果

Tongue-base suspension in conjunction with uvulopalatopharyngoplasty for treatment of severe obstructive sleep apnea: long-term follow-up results.

作者信息

Vicente Eugenio, Marín José M, Carrizo Santiago, Naya M J

机构信息

ENT Department, Hospital Universitario Miguel Servet, Zaragoza, Spain.

出版信息

Laryngoscope. 2006 Jul;116(7):1223-7. doi: 10.1097/01.mlg.0000224498.09015.d9.

DOI:10.1097/01.mlg.0000224498.09015.d9
PMID:16826064
Abstract

OBJECTIVES/HYPOTHESIS: To evaluate the usefulness of tongue-base suspension (TBS) in addition to uvulopalatopharyngoplasty (UPPP) in the treatment of obstructive sleep apnea syndrome (OSAS).

STUDY DESIGN

Long-term prospective case series.

SETTING

University tertiary care medical center.

METHODS

Fifty-five consecutive patients with severe OSAS (apnea-hypopnea index [AHI] 52.8+/-14.9 events/hr) with multilevel upper airway obstruction who refused treatment with continuous positive airway pressure underwent UPPP plus TBS with the Repose system. All patients were evaluated before surgery by clinical history, Epworth Sleepiness Scale (ESS), fiberoptic nasopharyngoscopy with Müller maneuver, and nocturnal polysomnography (PSG). After 3 years of surgery, all patients were re-evaluated at the clinic and had ESS test and full PSG. Surgical success was defined when the ESS dropped bellow 11, and the AHI decreased below the threshold of 20 events per hour of sleep and at least 50% from the preoperative value

RESULTS

There were 42 (78%) patients in which the AHI score decreased more than 50%, the AHI was lower than 20 events/hr in the PSG, and the ESS was lower than 11 after 3-years of follow-up (surgical success index). Logistic regression analysis demonstrated that body mass index at baseline was the only variable with significant statistical power to predict surgical success (odds ratio 0.85; 0.73-0.95, 95% confidence interval, P<.01)

CONCLUSION

When associated with UPPP, the TBS technique performed with the Repose system demonstrates a surgical success of up to 78% for patients with severe OSA who refused nasal continuous positive airway pressure.

摘要

目的/假设:评估舌根悬吊术(TBS)联合悬雍垂腭咽成形术(UPPP)治疗阻塞性睡眠呼吸暂停综合征(OSAS)的有效性。

研究设计

长期前瞻性病例系列研究。

研究地点

大学三级医疗中心。

方法

55例连续的重度OSAS患者(呼吸暂停低通气指数[AHI]为52.8±14.9次/小时),存在多平面上气道阻塞,拒绝持续气道正压通气治疗,接受了使用Repose系统的UPPP联合TBS手术。所有患者术前均通过临床病史、Epworth嗜睡量表(ESS)、纤维鼻咽喉镜检查及Müller动作、夜间多导睡眠图(PSG)进行评估。术后3年,所有患者在门诊进行复查,并进行ESS测试和完整的PSG检查。手术成功的定义为ESS降至11分以下,AHI降至每小时睡眠中20次事件以下,且较术前值降低至少50%。

结果

42例(78%)患者在随访3年后AHI评分降低超过50%,PSG中AHI低于20次/小时,ESS低于11分(手术成功指标)。逻辑回归分析表明,基线体重指数是唯一具有显著统计学意义预测手术成功的变量(比值比0.85;0.73 - 0.95,95%置信区间,P <.01)。

结论

对于拒绝鼻持续气道正压通气的重度OSA患者,使用Repose系统进行的TBS技术联合UPPP手术成功率高达78%。

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