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围手术期及危重症患者血糖异常——控制冰山一角

Perioperative and critical illness dysglycemia--controlling the iceberg.

作者信息

Keegan Mark T, Goldberg Michael E, Torjman Marc C, Coursin Douglas B

机构信息

Mayo Clinic, Rochester, Minnesota, USA.

出版信息

J Diabetes Sci Technol. 2009 Nov 1;3(6):1288-91. doi: 10.1177/193229680900300608.

DOI:10.1177/193229680900300608
PMID:20144382
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2787028/
Abstract

Patients with dysglycemia related to known or unrecognized diabetes, stress hyperglycemia, or hypoglycemia in the presence or absence of exogenous insulin routinely require care during the perioperative period or critical illness. Recent single and multicenter studies, a large multinational study, and three meta-analyses evaluated the safety of routine tight glycemic control (80-110 mg/dl) in critically ill adults. Results led to a call for more modest treatment goals (initiation of insulin at a blood glucose >180 mg/dl with a goal of approximately 150 mg/dl). In this symposium, an international group of multidisciplinary experts discusses the role of tight glycemic control, glucose measurement technique and its accuracy, glucose variability, hypoglycemia, and innovative methods to facilitate glucose homeostasis in this heterogeneous patient population.

摘要

患有与已知或未识别的糖尿病、应激性高血糖或低血糖相关的血糖异常(无论是否存在外源性胰岛素)的患者,在围手术期或危重病期间通常需要护理。最近的单中心和多中心研究、一项大型跨国研究以及三项荟萃分析评估了危重症成人常规严格血糖控制(80-110mg/dl)的安全性。结果促使人们呼吁采用更适度的治疗目标(血糖>180mg/dl时开始使用胰岛素,目标约为150mg/dl)。在本次研讨会上,一组国际多学科专家讨论了严格血糖控制的作用、血糖测量技术及其准确性、血糖变异性、低血糖以及促进这一异质性患者群体血糖稳态的创新方法。

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J Res Med Sci. 2012 Jul;17(7):694-709.
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本文引用的文献

1
Scientific principles and clinical implications of perioperative glucose regulation and control.围手术期血糖调节与控制的科学原理及临床意义。
Anesth Analg. 2010 Feb 1;110(2):478-97. doi: 10.1213/ANE.0b013e3181c6be63.
2
Analysis of guidelines for screening diabetes mellitus in an ambulatory population.门诊人群糖尿病筛查指南分析。
Mayo Clin Proc. 2010 Jan;85(1):27-35. doi: 10.4065/mcp.2009.0289.
3
A prospective randomised multi-centre controlled trial on tight glucose control by intensive insulin therapy in adult intensive care units: the Glucontrol study.一项关于在成人重症监护病房中通过强化胰岛素治疗实现严格血糖控制的前瞻性随机多中心对照试验:Glucontrol 研究。
Intensive Care Med. 2009 Oct;35(10):1738-48. doi: 10.1007/s00134-009-1585-2. Epub 2009 Jul 28.
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Glucose control in critically ill patients.
N Engl J Med. 2009 Jul 2;361(1):91; author reply 91-2.
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Glucose control in critically ill patients.
N Engl J Med. 2009 Jul 2;361(1):90; author reply 91-2.
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Glucose control in critically ill patients.
N Engl J Med. 2009 Jul 2;361(1):90-1; author reply 91-2.
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Glucose control in critically ill patients.危重症患者的血糖控制
N Engl J Med. 2009 Jul 2;361(1):90; author reply 91-2.
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Glucose control in critically ill patients.危重症患者的血糖控制
N Engl J Med. 2009 Jul 2;361(1):89-90; author reply 91-2.
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Glucose control in critically ill patients.危重症患者的血糖控制
N Engl J Med. 2009 Jul 2;361(1):89; author reply 91-2. doi: 10.1056/NEJMc090812.
10
The impact of glycemic control and diabetes mellitus on perioperative outcomes after total joint arthroplasty.血糖控制和糖尿病对全关节置换术后围手术期结局的影响。
J Bone Joint Surg Am. 2009 Jul;91(7):1621-9. doi: 10.2106/JBJS.H.00116.