Addictive potential: A=E/T(max)xt(1/2).

This hypothesis named Salerian Addictive Potential (SAP) suggests that the addictive potency of any substance may be calculated with an algebraic equation of A=E/T(max)xt(1/2), where A is the addictive potency, E represents the euphoric potency, T(max) is the time to reach peak plasma concentration, and t(1/2) is the plasma elimination half-life. This review offers medical evidence to suggest there is a negative association between the addictive potency of a substance and T(max) and t(1/2), whereas the euphoric potency of a substance increases its addictive potency. SAP seems incompatible with the current FDA and government sponsored schedule for classification of addictive substances.