Neuroscience Institute, Georgia State University, 38 Peachtree Center Ave, 806 GCB, Atlanta, GA 30303, USA.
Front Neuroendocrinol. 2010 Apr;31(2):193-202. doi: 10.1016/j.yfrne.2010.02.001. Epub 2010 Feb 6.
Over the last several decades, the relative contribution of early life events to individual disease susceptibility has been explored extensively. Only fairly recently, however, has it become evident that abnormal or excessive nociceptive activity experienced during the perinatal period may permanently alter the normal development of the CNS and influence future responses to somatosensory input. Given the significant rise in the number of premature infants receiving high-technology intensive care over the last 20 years, ex-preterm neonates may be exceedingly vulnerable to the long-term effects of repeated invasive interventions. The present review summarizes available clinical and laboratory findings on the lasting impact of exposure to noxious stimulation during early development, with a focus on the structural and functional alterations in nociceptive circuits, and its sexually dimorphic impact.
在过去的几十年中，人们广泛探讨了早期生活事件对个体疾病易感性的相对贡献。然而，直到最近，人们才意识到，围产期经历的异常或过度的伤害性活动可能会永久改变中枢神经系统的正常发育，并影响对体感输入的未来反应。鉴于过去 20 年来接受高科技强化护理的早产儿数量显著增加，早产儿可能极易受到反复侵入性干预的长期影响。本综述总结了目前关于早期发育过程中暴露于有害刺激的持久影响的临床和实验室发现，重点是伤害性回路的结构和功能改变及其性别二态影响。
