Kapur R P, Mahony B S, Nyberg D A, Resta R G, Shepard T H
Department of Pathology, University of Washington, Seattle 98195.
Teratology. 1991 Feb;43(2):103-8. doi: 10.1002/tera.1420430202.
A case is presented of twin gestation in which one gestational sac was completely resorbed and the remaining twin was subsequently found to be sirenomelic. First-trimester prenatal ultrasound examination demonstrated a second gestational sac that disappeared 2 weeks later. The sonographic features that led to the diagnosis of sirenomelia in the remaining fetus included severe renal dysgenesis, persistently apposed lower extremities, and absence of fibulae. Postmortem examination, including angiographic studies of the fetus, revealed caudal dysgenesis and a single umbilical artery that arose from the abdominal aorta. Sirenomelia occurs more frequently in twin gestations than in singletons. This case suggests that the association between twinning and sirenomelia may be greater than is currently recognized. Two hypotheses are given to explain this association.
本文报告一例双胎妊娠病例，其中一个妊娠囊完全吸收，随后发现存活的胎儿为并腿畸形。孕早期产前超声检查显示有第二个妊娠囊，但2周后消失。导致剩余胎儿被诊断为并腿畸形的超声特征包括严重肾发育不全、下肢持续并拢和腓骨缺如。尸体解剖检查，包括对胎儿的血管造影研究，显示尾部发育不全和一条发自腹主动脉的单脐动脉。并腿畸形在双胎妊娠中比单胎妊娠更常见。该病例表明双胎与并腿畸形之间的关联可能比目前所认识到的更大。给出了两种假说来解释这种关联。
