Department of Molecular Cell Biology, Leiden University Medical Center, 2300RC Leiden, The Netherlands.
Cell. 2010 Feb 5;140(3):308-10. doi: 10.1016/j.cell.2010.01.034.
The tumor suppressor protein p53, a crucial player in the DNA damage response, is regulated in many ways, most notably through ubiquitination. In this issue, Yuan et al. (2010) identify the deubiquitinating protease USP10 as a new regulator of p53 in the DNA damage response and tumor development.
肿瘤抑制蛋白 p53 是 DNA 损伤反应中的关键因子，其受到多种方式的调控，其中最为重要的调控方式是泛素化。在本期杂志中，Yuan 等人（2010）发现去泛素化酶 USP10 是 DNA 损伤反应和肿瘤发生中 p53 的一个新的调控因子。
