Inserm UMR S938, centre de recherche Saint-Antoine, université Pierre-et-Marie-Curie (université Paris-6), 184, rue du faubourg-Saint-Antoine, 75571 Paris cedex 12, France.
Clin Res Hepatol Gastroenterol. 2011 Feb;35(2):98-104. doi: 10.1016/j.gcb.2010.10.002. Epub 2010 Dec 21.
Abnormalities of the p53 tumor suppressor gene are among the most frequent molecular events in human neoplasia. p53 is consequently one of the most studied proteins, and is the subject of over 55,500 scientific papers. In this review, attention is focused on the functions of p53 in DNA repair. We highlight the recent progress in the analysis of protein signals to p53, including PARPs, and ubiquitination cascade proteins MDM2, CRM1, USP10 and 14-3-3σ.
p53 肿瘤抑制基因的异常是人类肿瘤中最常见的分子事件之一。因此，p53 是研究最多的蛋白质之一，相关科学论文超过 55500 篇。在这篇综述中，我们将重点关注 p53 在 DNA 修复中的功能。我们强调了分析 p53 蛋白信号的最新进展，包括 PARPs 以及泛素化级联蛋白 MDM2、CRM1、USP10 和 14-3-3σ。
