Chromosome Segregation Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3PX, UK.
Curr Biol. 2010 Feb 9;20(3):R101-3. doi: 10.1016/j.cub.2010.01.001.
Separase is the protease that cleaves the cohesive link between sister chromatids to trigger chromosome segregation in mitosis and meiosis. This enzyme is known to orchestrate additional mitotic events and we now gain new insight into how it promotes cytokinesis in the nematode Caenorhabditis elegans.
有丝分裂和减数分裂过程中，分离酶（separase）可将姐妹染色单体之间的黏连蛋白水解，从而引发染色体分离。该酶还参与调控有丝分裂的其他事件，我们现在对其在秀丽隐杆线虫（Caenorhabditis elegans）中促进胞质分裂的机制有了新的认识。
