细菌入侵：自噬与先天免疫的联系。

Bacterial invasion: linking autophagy and innate immunity.

机构信息

INSERM, U848, F-94805 Villejuif, France; Institut Gustave Roussy, F-94805 Villejuif, France.

出版信息

Curr Biol. 2010 Feb 9;20(3):R106-8. doi: 10.1016/j.cub.2009.12.016.

DOI:10.1016/j.cub.2009.12.016

PMID:20144769

Abstract

Crohn's disease is a chronic inflammatory bowel disorder that has been associated with polymorphisms in the genes encoding the pattern-recognition receptor NOD2 and the autophagic regulator ATG16L1. A new study demonstrates that NOD2 recruits ATG16L1 at bacterial entry sites, thereby bridging innate immunity and autophagy.

摘要

克罗恩病是一种慢性炎症性肠病，与编码模式识别受体 NOD2 和自噬调节剂 ATG16L1 的基因多态性有关。一项新的研究表明，NOD2 在细菌进入部位募集 ATG16L1，从而连接先天免疫和自噬。