Division of Infectious Diseases, Department of Microbiology and Carol Yu Centre for Infection, the University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Pokfulam, Hong Kong SAR, China.
J Infect. 2010 Apr;60(4):286-92. doi: 10.1016/j.jinf.2010.02.002. Epub 2010 Feb 8.
To investigate the epidemiology of fecal carriage of CTX-M type extended-spectrum beta-lactamases (ESBL)-producing organisms among children and their household contacts.
Fecal carriage with CTX-M-producing organisms was studied in 53 children and 172 household members. Molecular methods were used to characterize the isolates.
The children were mostly healthy and hospitalized for relatively mild febrile illnesses. Overall, the prevalence of fecal carriage of CTX-M-producing bacteria was 43.5% (admission children, 37.7%; household children, 20.7% and household adults, 50.3%). Household colonization index (defined by number of household carriers/total number of members) was significantly higher among families with at least one individual having a history of prolonged (>3 months) out-of-town residence in the previous year (mean+/-standard deviation; yes group, 0.67+/-0.36 vs. no group, 0.39+/-0.28, P=0.009) and was inversely correlated with the living space per person (R-square=0.139, P=0.006). Among 29 households with at least two carriers of CTX-M-producing enterobacteria, six clusters of clonally related strains were shared by 15 individuals from seven households; with both intra- and inter-household transmission.
CTX-M beta-lactamases may spread extensively amongst family members in the home.
研究儿童及其家庭接触者中产 CTX-M 型超广谱β-内酰胺酶（ESBL）的肠杆菌科细菌的粪便携带情况。
研究了 53 名儿童和 172 名家庭成员的 CTX-M 产生菌粪便携带情况。采用分子方法对分离株进行了特征分析。
儿童大多健康，因相对较轻的发热性疾病住院。总体而言，CTX-M 产细菌的粪便携带率为 43.5%（住院儿童为 37.7%；家庭儿童为 20.7%，家庭成人为 50.3%）。家庭定植指数（定义为家庭携带者数/成员总数）在过去 1 年中至少有 1 人有外出（>3 个月）居住史的家庭中显著较高（平均值+/-标准差；是组为 0.67+/-0.36，否组为 0.39+/-0.28，P=0.009），且与人均居住空间呈负相关（R 平方=0.139，P=0.006）。在 29 个至少有 2 名 CTX-M 产肠杆菌科细菌携带者的家庭中，有 6 个克隆相关株的簇在 7 个家庭的 15 个人之间共享；存在家庭内和家庭间传播。
CTX-M 型β-内酰胺酶可能在家中家庭成员之间广泛传播。
