Department of Geriatric Medicine, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL, UK.
J Neurol Neurosurg Psychiatry. 2010 Feb;81(2):157-9. doi: 10.1136/jnnp.2008.164483.
To compare the performance of patients with mild-moderate Alzheimer's disease (AD) and vascular dementia (VaD) on tests of information processing and attention.
Patients with AD (n=75) and VaD (n=46) were recruited from a memory clinic along with dementia-free participants (n=28). They underwent specific tests of attention from the Cognitive Drug Research battery, and pen and paper tests including Colour Trails A and B and Stroop. All patients had a CT brain scan that was independently scored for white-matter change/ischaemia.
Attention was impaired in both AD and VaD patients. VaD patients had more impaired choice reaction times and were less accurate on a vigilance test measuring sustained attention. Deficits in selective and divided attention occurred in both patient groups and showed the strongest correlations with Mini Mental State Examination scores.
This study demonstrates problems with the attentional network in mild-moderate AD and VaD. The authors propose that attention should be tested routinely in a memory clinic setting.
比较轻度至中度阿尔茨海默病（AD）和血管性痴呆（VaD）患者在信息处理和注意力测试上的表现。
从记忆门诊招募了 75 名 AD 患者和 46 名 VaD 患者，以及 28 名无痴呆症的参与者。他们接受了认知药物研究电池中的特定注意力测试，以及纸笔测试，包括色迹 A 和 B 以及斯特鲁普测试。所有患者均进行了 CT 脑部扫描，该扫描由独立的脑白质改变/缺血评分。
AD 和 VaD 患者的注意力均受损。VaD 患者的选择反应时间更差，警觉性测试的持续注意力准确性更低。选择性和分散性注意力缺陷在两个患者组中均发生，与简易精神状态检查表评分相关性最强。
本研究表明，轻度至中度 AD 和 VaD 患者的注意力网络存在问题。作者建议在记忆门诊常规测试注意力。
