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健康与神经退行性衰老中执行功能能力的评估——一项选择性文献综述

The assessment of executive function abilities in healthy and neurodegenerative aging-A selective literature review.

作者信息

Idowu Mojitola I, Szameitat Andre J, Parton Andrew

机构信息

Centre for Cognitive and Clinical Neuroscience (CCN), College of Health, Medicine and Life Sciences, Division of Psychology, Department of Life Sciences, Brunel University London, Uxbridge, United Kingdom.

出版信息

Front Aging Neurosci. 2024 Mar 26;16:1334309. doi: 10.3389/fnagi.2024.1334309. eCollection 2024.

DOI:10.3389/fnagi.2024.1334309
PMID:38596597
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11002121/
Abstract

Numerous studies have examined executive function (EF) abilities in cognitively healthy older adults and those living with mild cognitive impairment (MCI) and Alzheimer's disease (AD). Currently, there are no standard accepted protocols for testing specific EFs; thus, researchers have used their preferred tool, which leads to variability in assessments of decline in a particular ability across studies. Therefore, there is a need for guidance as to the most sensitive tests for assessing EF decline. A search of the most current literature published between 2000 and 2022 on EF studies assessing cognitively healthy older adults and individuals living with MCI and AD was conducted using PubMed/Medline, PsycINFO, Embase, Web of Science, and Google Scholar. Emphasis was placed on the EF's dual-tasking, inhibition, shifting or switching, and working memory updating. Many tasks and their outcomes were reviewed. Of particular importance was the difference in outcomes for tasks applied to the same group of participants. These various EF assessment tools demonstrate differences in effectively identifying decline in EF ability due to the aging process and neurodegenerative conditions, such as MCI and AD. This review identifies various factors to consider in using particular EF tasks in particular populations, including task demand and stimuli factors, and also when comparing differing results across studies.

摘要

许多研究已经考察了认知健康的老年人以及患有轻度认知障碍(MCI)和阿尔茨海默病(AD)的人群的执行功能(EF)能力。目前,尚无用于测试特定执行功能的标准公认方案;因此,研究人员使用了他们偏爱的工具,这导致不同研究中对特定能力下降的评估存在差异。因此,需要就评估执行功能下降的最敏感测试提供指导。我们使用PubMed/Medline、PsycINFO、Embase、科学网和谷歌学术对2000年至2022年期间发表的关于评估认知健康的老年人以及患有MCI和AD的个体的执行功能研究的最新文献进行了检索。重点关注执行功能的双任务处理、抑制、转换或切换以及工作记忆更新。对许多任务及其结果进行了综述。特别重要的是应用于同一组参与者的任务在结果上的差异。这些各种执行功能评估工具在有效识别由于衰老过程以及神经退行性疾病(如MCI和AD)导致的执行功能能力下降方面表现出差异。本综述确定了在特定人群中使用特定执行功能任务时需要考虑的各种因素,包括任务需求和刺激因素,以及在比较不同研究的不同结果时需要考虑的因素。