Institut National de la Santé et de la Recherche Médicale U805, Villejuif, France.
Cancer Res. 2010 Feb 15;70(4):1281-5. doi: 10.1158/0008-5472.CAN-09-3276. Epub 2010 Feb 9.
Exosomes are nanovesicles originating from late endosomal compartments and secreted by most living cells in ex vivo cell culture conditions. The interest in exosomes was rekindled when B-cell and dendritic cell-derived exosomes were shown to mediate MHC-dependent immune responses. Despite limited understanding of exosome biogenesis and physiological relevance, accumulating evidence points to their bioactivity culminating in clinical applications in cancer. This review focuses on the preclinical studies exploiting the immunogenicity of dendritic cell-derived exosomes (Dex) and will elaborate on the past and future vaccination trials conducted using Dex strategy in melanoma and non-small cell lung cancer patients.
外泌体是起源于晚期内体隔室并由大多数活细胞在离体细胞培养条件下分泌的纳米囊泡。当发现 B 细胞和树突状细胞来源的外泌体介导 MHC 依赖性免疫反应时，人们对外泌体的兴趣重新燃起。尽管对外泌体的生物发生和生理相关性的了解有限，但越来越多的证据表明，它们的生物活性最终导致了在癌症中的临床应用。本综述重点介绍了利用树突状细胞衍生的外泌体（Dex）的免疫原性的临床前研究，并详细阐述了过去和未来使用 Dex 策略在黑色素瘤和非小细胞肺癌患者中进行的疫苗试验。
