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外泌体与癌症的关系:形成、诊断及治疗

Relationship between exosomes and cancer: formation, diagnosis, and treatment.

作者信息

Huang Chen, Li Jiajin, Xie Zichuan, Hu Xiangjun, Huang Yan

机构信息

Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.

Sichuan university, West China Hospital of Sichuan University, Chengdu 610041, China.

出版信息

Int J Biol Sci. 2025 Jan 1;21(1):40-62. doi: 10.7150/ijbs.95763. eCollection 2025.

Abstract

Exosomes are a member of extracellular vesicles. However, their biological characteristics differ from those of other vesicles, and recently, their powerful functions as information molecules, biomarkers, and carriers have been demonstrated. Malignancies are the leading cause of high morbidity and mortality worldwide. The cure rate of malignancies can be improved by improving early screening rates and therapy. Moreover, a close correlation between exosomes and malignancies has been observed. An in-depth study of exosomes can provide new methods for diagnosing and treating tumors. Therefore, this study aimed to review, sort, and summarize such achievements, and present ideas and opinions on the application of exosomes in tumor treatment.

摘要

外泌体是细胞外囊泡的一种。然而,它们的生物学特性与其他囊泡不同,最近,其作为信息分子、生物标志物和载体的强大功能已得到证实。恶性肿瘤是全球高发病率和高死亡率的主要原因。通过提高早期筛查率和治疗水平可以提高恶性肿瘤的治愈率。此外,人们还观察到外泌体与恶性肿瘤之间存在密切关联。对外泌体进行深入研究可为肿瘤的诊断和治疗提供新方法。因此,本研究旨在回顾、梳理和总结这些成果,并就外泌体在肿瘤治疗中的应用提出思路和见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/759f/11667803/8952e5e8965e/ijbsv21p0040g001.jpg

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