Hirata Yasunobu, Nagata Daisuke, Suzuki Etsu, Nishimatsu Hiroaki, Suzuki Jun-Ichi, Nagai Ryozo
Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo.
Int Heart J. 2010 Jan;51(1):1-6. doi: 10.1536/ihj.51.1.
Vascular endothelial dysfunction reflected by reduced nitric oxide (NO) availability is certainly the causative factor or promoting mechanism of arteriosclerosis. It is necessary to detect endothelial dysfunction at an early stage using appropriate methods, and to choose a treatment for the recovery of endothelial function. There are nonpharmacological and pharmacological therapies to attain endothelial repair. The former includes body weight reduction, aerobic exercise, and restriction of salt intake, while the latter includes the use of renin-angiotensin system inhibitors, calcium antagonists, some types of beta blockers, statins, erythropoietin, tetrahydrobiopterin, and antioxidants. These therapies are intended to increase NO synthase activity and NO release, inhibit NO degradation, and enhance the activity of endothelial progenitor cells.
一氧化氮（NO）可用性降低所反映的血管内皮功能障碍无疑是动脉硬化的致病因素或促进机制。有必要使用适当的方法早期检测内皮功能障碍，并选择恢复内皮功能的治疗方法。有非药物和药物疗法来实现内皮修复。前者包括减轻体重、有氧运动和限制盐摄入，而后者包括使用肾素-血管紧张素系统抑制剂、钙拮抗剂、某些类型的β受体阻滞剂、他汀类药物、促红细胞生成素、四氢生物蝶呤和抗氧化剂。这些疗法旨在增加一氧化氮合酶活性和一氧化氮释放，抑制一氧化氮降解，并增强内皮祖细胞的活性。
