17β-雌二醇-3-葡萄糖醛酸苷和雌酮-3-葡萄糖醛酸苷在兔体内的代谢

The metabolism of 17beta-estradiol-3-glucosiduronate and estrone-3-glucosiduronate in the rabbit.

作者信息

Miyazaki T, Mizukoshi H, Araki Y

出版信息

Endocrinol Jpn. 1977 Oct;24(5):503-6. doi: 10.1507/endocrj1954.24.503.

DOI:10.1507/endocrj1954.24.503

PMID:201455

Abstract

[6, 7-3H]-17beta-Estradiol-3-glucosiduronate, [6, 7-3H]-estrone-3-glucosiduronate or [6, 7-3H]-estrone was administered intravenously into the rabbit, and analysis and identification of the urinary metabolites were carried out. In either case, the major urinary metabolite was found to be a diconjugate. The sequential enzymic hydrolysis indicated that this diconjugate was glucosiduronate-N-acetyglucosaminide of 17alpha-estradiol. From these results, the conversion of the estrogen glucosiduronate into a diconjugate was thought a rather universal phenomenon in the rabbit.

摘要

将[6, 7 - ³H] - 17β - 雌二醇 - 3 - 葡萄糖醛酸苷、[6, 7 - ³H] - 雌酮 - 3 - 葡萄糖醛酸苷或[6, 7 - ³H] - 雌酮静脉注射给兔子，并对尿液代谢产物进行分析和鉴定。在任何一种情况下，发现主要的尿液代谢产物都是双共轭物。连续酶促水解表明，这种双共轭物是17α - 雌二醇的葡萄糖醛酸苷 - N - 乙酰葡糖胺。从这些结果来看，雌激素葡萄糖醛酸苷转化为双共轭物在兔子中被认为是一种相当普遍的现象。