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Neuropsychopharmacology. 2010 Mar;35(4):851-2. doi: 10.1038/npp.2009.206.
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3
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Molecular mechanisms of action and in vivo validation of an M4 muscarinic acetylcholine receptor allosteric modulator with potential antipsychotic properties.M4 毒蕈碱型乙酰胆碱受体变构调节剂的作用机制及其体内验证,具有潜在的抗精神病特性。
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Designing Hybrids Targeting the Cholinergic System by Modulating the Muscarinic and Nicotinic Receptors: A Concept to Treat Alzheimer's Disease.设计针对胆碱能系统的杂种分子:通过调节毒蕈碱和烟碱受体来治疗阿尔茨海默病的一种概念。
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Challenges in the development of an M PAM preclinical candidate: The discovery, SAR, and in vivo characterization of a series of 3-aminoazetidine-derived amides.MPAM临床前候选药物开发中的挑战:一系列3-氨基氮杂环丁烷衍生酰胺的发现、构效关系及体内特性研究
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本文引用的文献

1
Molecular mechanisms of action and in vivo validation of an M4 muscarinic acetylcholine receptor allosteric modulator with potential antipsychotic properties.M4 毒蕈碱型乙酰胆碱受体变构调节剂的作用机制及其体内验证,具有潜在的抗精神病特性。
Neuropsychopharmacology. 2010 Mar;35(4):855-69. doi: 10.1038/npp.2009.194. Epub 2009 Nov 25.
2
Allosteric modulation of the muscarinic M4 receptor as an approach to treating schizophrenia.作为治疗精神分裂症的一种方法,毒蕈碱M4受体的变构调节
Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10978-83. doi: 10.1073/pnas.0800567105. Epub 2008 Aug 4.
3
The highly efficacious actions of N-desmethylclozapine at muscarinic receptors are unique and not a common property of either typical or atypical antipsychotic drugs: is M1 agonism a pre-requisite for mimicking clozapine's actions?去甲氯氮平对毒蕈碱受体的高效作用是独特的,并非典型或非典型抗精神病药物的共同特性:M1激动作用是模拟氯氮平作用的先决条件吗?
Psychopharmacology (Berl). 2005 Apr;178(4):451-60. doi: 10.1007/s00213-004-2017-1. Epub 2004 Oct 13.
4
The effects of diisopropylfluorophosphonate in schizophrenia and manic depressive psychosis.二异丙基氟磷酸酯在精神分裂症和躁狂抑郁症中的作用。
J Neurol Neurosurg Psychiatry. 1950 Feb;13(1):47-62. doi: 10.1136/jnnp.13.1.47.
5
Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia.神奇猎枪与神奇子弹:用于情绪障碍和精神分裂症的选择性非选择性药物
Nat Rev Drug Discov. 2004 Apr;3(4):353-9. doi: 10.1038/nrd1346.
6
Allosteric binding sites on cell-surface receptors: novel targets for drug discovery.细胞表面受体上的变构结合位点:药物发现的新靶点。
Nat Rev Drug Discov. 2002 Mar;1(3):198-210. doi: 10.1038/nrd746.
7
Hyperactivity, elevated dopaminergic transmission, and response to amphetamine in M1 muscarinic acetylcholine receptor-deficient mice.M1毒蕈碱型乙酰胆碱受体缺陷小鼠的多动、多巴胺能传递增强及对苯丙胺的反应
Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15312-7. doi: 10.1073/pnas.261583798.
8
Xanomeline, an M(1)/M(4) preferring muscarinic cholinergic receptor agonist, produces antipsychotic-like activity in rats and mice.占诺美林是一种优先作用于M(1)/M(4)的毒蕈碱胆碱能受体激动剂,在大鼠和小鼠中产生抗精神病样活性。
Schizophr Res. 2000 May 5;42(3):249-59. doi: 10.1016/s0920-9964(99)00138-3.
9
Enhancement of D1 dopamine receptor-mediated locomotor stimulation in M(4) muscarinic acetylcholine receptor knockout mice.M4毒蕈碱型乙酰胆碱受体基因敲除小鼠中D1多巴胺受体介导的运动刺激增强
Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10483-8. doi: 10.1073/pnas.96.18.10483.
10
Effects of xanomeline, a selective muscarinic receptor agonist, on cognitive function and behavioral symptoms in Alzheimer disease.选择性毒蕈碱受体激动剂占诺美林对阿尔茨海默病认知功能和行为症状的影响。
Arch Neurol. 1997 Apr;54(4):465-73. doi: 10.1001/archneur.1997.00550160091022.

Allosteric antipsychotics: m4 muscarinic potentiators as novel treatments for schizophrenia.

作者信息

Farrell Martilias, Roth Bryan L

机构信息

Division of Medicinal Chemistry, Department of Pharmacology, NIMH Psychoactive Drug Screening Program, University of North Carolina Chapel Hill Medical School, Chapel Hill, NC 27759, USA.

出版信息

Neuropsychopharmacology. 2010 Mar;35(4):851-2. doi: 10.1038/npp.2009.206.

DOI:10.1038/npp.2009.206
PMID:20145632
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3055359/
Abstract
摘要