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Allosteric antipsychotics: m4 muscarinic potentiators as novel treatments for schizophrenia.

作者信息

Farrell Martilias, Roth Bryan L

机构信息

Division of Medicinal Chemistry, Department of Pharmacology, NIMH Psychoactive Drug Screening Program, University of North Carolina Chapel Hill Medical School, Chapel Hill, NC 27759, USA.

出版信息

Neuropsychopharmacology. 2010 Mar;35(4):851-2. doi: 10.1038/npp.2009.206.

Abstract
摘要

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本文引用的文献

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Allosteric modulation of the muscarinic M4 receptor as an approach to treating schizophrenia.
Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10978-83. doi: 10.1073/pnas.0800567105. Epub 2008 Aug 4.
4
The effects of diisopropylfluorophosphonate in schizophrenia and manic depressive psychosis.
J Neurol Neurosurg Psychiatry. 1950 Feb;13(1):47-62. doi: 10.1136/jnnp.13.1.47.
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Allosteric binding sites on cell-surface receptors: novel targets for drug discovery.
Nat Rev Drug Discov. 2002 Mar;1(3):198-210. doi: 10.1038/nrd746.
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Enhancement of D1 dopamine receptor-mediated locomotor stimulation in M(4) muscarinic acetylcholine receptor knockout mice.
Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10483-8. doi: 10.1073/pnas.96.18.10483.

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