School of Psychology, Cardiff University, Tower Building, Park Place, Cardiff, CF10 3AT, UK.
Psychopharmacology (Berl). 2010 Apr;209(2):153-62. doi: 10.1007/s00213-010-1779-x. Epub 2010 Feb 10.
The N-methyl D-aspartate antagonist phencyclidine (PCP) is purported to mimic the negative, cognitive and positive symptoms of schizophrenia. Thus, acute and sub-chronic PCP treatment in rodents might produce anhedonia, a decrease in the pleasure produced by rewards.
Experiment 1 investigated whether acute PCP treatment changes the value of sucrose. A comparison was made to (+)MK-801, a drug often used interchangeably with PCP in preclinical studies. Experiment 2 assessed the effects of withdrawal from sub-chronic PCP treatment on the value of sucrose.
Experiment 1 examined the dose-response effects of PCP and (+)MK-801 on licking microstructure during sucrose consumption. Experiment 2 assessed the effects of withdrawal from sub-chronic PCP treatment (5 mg/kg twice daily for 7 days), on licking microstructure during sucrose consumption. Locomotor activity testing was carried out in experiment 2 to confirm the sensitisation effect of the PCP regimen on amphetamine-induced hyperlocomotion.
Low to moderate acute doses of PCP and (+)MK-801 increased the amount of sucrose consumed. Higher doses decreased consumption and the number of licks per cluster (cluster size) but also increased the average inter-lick interval, which may indicate motor impairment. There was no evidence that withdrawal from sub-chronic PCP treatment produced decreases in consumption or lick cluster size.
Following acute PCP treatment, we found no evidence of reduced reward value without the presence of confounding motor deficits. Sub-chronic PCP withdrawal also produced no decrease in reward value. Therefore, the current results indicate that neither acute PCP treatment nor sub-chronic PCP withdrawal produce consummatory anhedonia.
N-甲基-D-天冬氨酸拮抗剂苯环已哌啶（PCP）据称可模拟精神分裂症的阴性、认知和阳性症状。因此，PCP 对啮齿动物的急性和亚慢性治疗可能会导致快感缺失，即奖励产生的愉悦感下降。
实验 1 研究了急性 PCP 治疗是否会改变蔗糖的价值。与（+）MK-801 进行了比较，（+）MK-801 是临床前研究中常与 PCP 互换使用的药物。实验 2 评估了亚慢性 PCP 治疗戒断对蔗糖价值的影响。
实验 1 考察了 PCP 和（+）MK-801 对蔗糖消耗期间舔舐微观结构的剂量反应效应。实验 2 评估了亚慢性 PCP 治疗（5mg/kg，每日两次，持续 7 天）戒断对蔗糖消耗期间舔舐微观结构的影响。在实验 2 中进行了运动活动测试，以确认 PCP 方案对安非他命诱导的过度活跃的敏化作用。
低至中等剂量的急性 PCP 和（+）MK-801 增加了蔗糖的消耗量。较高剂量会降低消耗量和每个舔舐簇的次数（簇大小），但也会增加平均舔舐间隔，这可能表明运动障碍。没有证据表明亚慢性 PCP 治疗戒断会导致消耗或舔舐簇大小减少。
在急性 PCP 治疗后，我们没有发现没有运动障碍混杂的情况下奖励价值降低的证据。亚慢性 PCP 戒断也没有降低奖励价值。因此，目前的结果表明，急性 PCP 治疗或亚慢性 PCP 戒断都不会产生消费性快感缺失。
