Pavlova T V, Fesenko G N, Gekht A B, Gulyaeva N V, Koval'zon V M
Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, 5a Butlerov Street, 117865, Moscow, Russia.
Neurosci Behav Physiol. 2010 Mar;40(3):239-44. doi: 10.1007/s11055-010-9249-9. Epub 2010 Feb 10.
Studies on rats divided into two groups with different sensitivities on the basis of manifest convulsive activity in response to pentylenetetrazol kindling showed that both "tolerant" and "sensitive" rats showed convulsive discharges on EEG traces. However, as compared with values in "tolerant" rats, the number of convulsive discharges in "sensitive" rats was 60% greater, convulsive discharges occurred 45 sec later, and had a duration in the first 45 post-injection minutes which was 70% longer. There was no difference between the mean durations of convulsive discharges in the two groups. The EEG frequency power peak in "tolerant" rats was more marked than that in "sensitive" animals, and was located at 7.2 Hz. These data led to the conclusion that pentylenetetrazol kindling induces epileptic activity on the EEG in rats independently of whether or not the animals showed behavioral seizures, though there were significant differences in measures of this activity in "sensitive" and "tolerant" rats.
根据对戊四氮点燃反应的明显惊厥活动，将大鼠分为两组，敏感性不同。研究表明，“耐受”和“敏感”大鼠的脑电图（EEG）轨迹上均出现惊厥放电。然而，与“耐受”大鼠相比，“敏感”大鼠的惊厥放电次数多60%，惊厥放电在45秒后出现，且在注射后的前45分钟内持续时间长70%。两组惊厥放电的平均持续时间没有差异。“耐受”大鼠的EEG频率功率峰值比“敏感”动物更明显，位于7.2Hz。这些数据得出的结论是，戊四氮点燃可在大鼠EEG上诱发癫痫活动，而与动物是否表现出行为性癫痫发作无关，尽管“敏感”和“耐受”大鼠在这种活动的测量上存在显著差异。
