Caine M, Gin S, Pietra C, Ruffmann R
Department of Urology, Hadassah Medical Center, Jerusalem, Israel.
Urology. 1991 Apr;37(4):390-4. doi: 10.1016/0090-4295(91)80275-c.
The antispasmodic effects of the flavone compounds flavoxate hydrochloride, 3-methylflavone carboxylic acid (MFCA), and REC 15/2053 (and in the case of the detrusor, oxybutynin), on the human detrusor, prostatic adenoma, prostatic capsule, and bladder neck, were studied by the in vitro isometric method. All the compounds inhibited, in different orders of potency, potassium-induced contractions of the tissues. Flavoxate showed a slightly greater activity than the other two compounds in the prostatic and bladder neck tissues. However, REC 15/2053 displayed greater activity in the detrusor than in the other tissues. The relaxant effect on the prostatic tissues suggests a potential use for these compounds in benign prostatic obstruction.
采用体外等长法研究了黄酮类化合物盐酸黄酮哌酯、3 - 甲基黄酮羧酸（MFCA）和REC 15/2053（对于逼尿肌，还研究了奥昔布宁）对人逼尿肌、前列腺腺瘤、前列腺包膜和膀胱颈的解痉作用。所有化合物均以不同的效力顺序抑制组织的钾诱导收缩。黄酮哌酯在前列腺和膀胱颈组织中的活性略高于其他两种化合物。然而，REC 15/2053在逼尿肌中的活性高于其他组织。对前列腺组织的松弛作用表明这些化合物在良性前列腺梗阻中具有潜在用途。
