骨关节炎膝关节内侧股骨髁软骨丢失的空间模式：来自骨关节炎倡议的数据。
Spatial patterns of cartilage loss in the medial femoral condyle in osteoarthritic knees: data from the Osteoarthritis Initiative.
机构信息
Chondrometrics GmbH, Ainring, Germany.
出版信息
Magn Reson Med. 2010 Mar;63(3):574-81. doi: 10.1002/mrm.22194.
Abstract
The objective of this study was to develop a technique for analyzing spatial patterns of cartilage loss in the medial femoral condyle (MF), and to study MF cartilage loss in participants of the Osteoarthritis Initiative. Using a 0.7 mm sagittal double echo at steady state (DESS) sequence, 160 osteoarthritic knees from 80 participants with varying degrees of medial joint space narrowing were imaged at baseline and 1-year follow-up. MF cartilage was segmented and cartilage loss determined. Rate of change varied significantly (P = 0.0067) along the anterior-posterior extension of the MF, with the greatest changes (-45 microm, -2.7%) observed 30-60 degrees posterior to the trochlear notch. The rate was greater in the central MF after excluding peripheral aspects of the MF from analysis. Sensitivity to change was greatest at 45-75 degrees (standardized response mean = -0.32) but was minimally affected by medial-lateral trimming. In conclusion, the greatest sensitivity to change was achieved when analyzing the posterior aspect of the central, weight-bearing MF.
摘要
本研究旨在开发一种分析股骨内侧髁（MF）软骨丢失空间模式的技术，并研究 Osteoarthritis Initiative 参与者的 MF 软骨丢失情况。使用 0.7mm 矢状面双回波稳态（DESS）序列，对 80 名参与者的 160 个膝关节进行了基线和 1 年随访的成像，这些参与者的内侧关节间隙狭窄程度不同。对 MF 软骨进行分割并确定软骨丢失情况。MF 前-后延伸方向上的变化率差异有统计学意义（P = 0.0067），滑车切迹后 30-60 度处观察到最大变化（-45 微米，-2.7%）。排除 MF 外周部分后，MF 中央的变化率更大。在 45-75 度时，变化的敏感性最大（标准化反应均值=-0.32），但受内外修剪的影响最小。总之，当分析中央负重 MF 的后部时，可获得最大的变化敏感性。
相似文献
1
Spatial patterns of cartilage loss in the medial femoral condyle in osteoarthritic knees: data from the Osteoarthritis Initiative.骨关节炎膝关节内侧股骨髁软骨丢失的空间模式：来自骨关节炎倡议的数据。
Magn Reson Med. 2010 Mar;63(3):574-81. doi: 10.1002/mrm.22194.
2
Magnitude and regional distribution of cartilage loss associated with grades of joint space narrowing in radiographic osteoarthritis--data from the Osteoarthritis Initiative (OAI).与放射学骨关节炎关节间隙狭窄程度相关的软骨丢失的幅度和区域分布——来自骨关节炎倡议（OAI）的数据。
Osteoarthritis Cartilage. 2010 Jun;18(6):760-8. doi: 10.1016/j.joca.2009.12.009. Epub 2010 Feb 18.
3
Sensitivity to change of cartilage morphometry using coronal FLASH, sagittal DESS, and coronal MPR DESS protocols--comparative data from the Osteoarthritis Initiative (OAI).基于冠状FLASH、矢状DESS 和冠状 MPR DESS 协议的软骨形态计量学改变的敏感性：来自骨关节炎倡议（OAI）的对比数据。
Osteoarthritis Cartilage. 2010 Apr;18(4):547-54. doi: 10.1016/j.joca.2009.12.003. Epub 2009 Dec 21.
4
Magnetic resonance imaging-based cartilage loss in painful contralateral knees with and without radiographic joint space narrowing: Data from the Osteoarthritis Initiative.基于磁共振成像的有或无影像学关节间隙变窄的疼痛对侧膝关节软骨损伤：来自骨关节炎倡议组织的数据。
Arthritis Rheum. 2009 Sep 15;61(9):1218-25. doi: 10.1002/art.24791.
5
Subregional laminar cartilage MR spin-spin relaxation times (T2) in osteoarthritic knees with and without medial femorotibial cartilage loss - data from the Osteoarthritis Initiative (OAI).伴或不伴股胫内侧软骨损伤的骨关节炎膝关节的亚区域层状软骨磁共振自旋-自旋弛豫时间（T2）——来自骨关节炎倡议组织（OAI）的数据
Osteoarthritis Cartilage. 2017 Aug;25(8):1313-1323. doi: 10.1016/j.joca.2017.03.013. Epub 2017 Mar 27.
6
Cartilage can be thicker in advanced osteoarthritic knees: a tridimensional quantitative analysis of cartilage thickness at posterior aspect of femoral condyles.晚期骨关节炎膝关节的软骨可能更厚：股骨髁后侧软骨厚度的三维定量分析
Br J Radiol. 2018 Jul;91(1087):20170729. doi: 10.1259/bjr.20170729. Epub 2018 Apr 16.
7
Quantitative measurement of femoral condyle cartilage in the knee by MRI: validation study by multireaders.膝关节股骨髁软骨的MRI定量测量：多阅片者验证研究
J Magn Reson Imaging. 2014 Apr;39(4):972-7. doi: 10.1002/jmri.24217. Epub 2013 Oct 7.
8
Investigation of regional influence of magic-angle effect on t2 in human articular cartilage with osteoarthritis at 3 T.3T下对骨关节炎患者人体关节软骨中魔角效应在T2上的区域影响的研究。
Acad Radiol. 2015 Jan;22(1):87-92. doi: 10.1016/j.acra.2014.07.015.
9
Osteoarthritic bone marrow lesions almost exclusively colocate with denuded cartilage: a 3D study using data from the Osteoarthritis Initiative.骨关节炎骨髓病变几乎完全与裸露的软骨共存：一项来自骨关节炎倡议的 3D 研究。
Ann Rheum Dis. 2016 Oct;75(10):1852-7. doi: 10.1136/annrheumdis-2015-208407. Epub 2015 Dec 15.
10
Change in cartilage morphometry: a sample of the progression cohort of the Osteoarthritis Initiative.软骨形态测量学的变化：骨关节炎倡议进展队列的一个样本。
Ann Rheum Dis. 2009 Mar;68(3):349-56. doi: 10.1136/ard.2007.082107. Epub 2008 Apr 13.
引用本文的文献
1
Evaluation of Cartilage Degeneration Using MRI T1ρ Mapping after Locomotion Training in Patients with Early Knee Osteoarthritis.早期膝关节骨关节炎患者运动训练后使用MRI T1ρ成像评估软骨退变情况
Prog Rehabil Med. 2025 Sep 5;10:20250020. doi: 10.2490/prm.20250020. eCollection 2025.
2
Comparison between coronal FLASH and sagittal double echo steady state MRI in detecting longitudinal cartilage thickness change by fully automated segmentation - Data from the FNIH biomarker cohort.通过全自动分割比较冠状面快速低角度激发序列（FLASH）和矢状面双回波稳态磁共振成像（MRI）检测软骨纵向厚度变化——来自美国国立卫生研究院（NIH）生物标志物队列的数据
Osteoarthr Cartil Open. 2025 Aug 5;7(3):100657. doi: 10.1016/j.ocarto.2025.100657. eCollection 2025 Sep.
3
Allogeneic umbilical cord blood-derived mesenchymal stem cell implantation versus microdrilling combined with high tibial osteotomy for cartilage regeneration.异体脐带血源间充质干细胞移植与微骨折术联合胫骨高位截骨术治疗软骨再生。
Sci Rep. 2024 Feb 9;14(1):3333. doi: 10.1038/s41598-024-53598-9.
4
Quantitative measurement of cartilage morphology in osteoarthritis: current knowledge and future directions.骨关节炎中软骨形态的定量测量：当前知识和未来方向。
Skeletal Radiol. 2023 Nov;52(11):2107-2122. doi: 10.1007/s00256-022-04228-w. Epub 2022 Nov 15.
5
Accuracy of magnetic resonance imaging in assessing knee cartilage changes over time in patients with osteoarthritis: A systematic review.磁共振成像评估骨关节炎患者膝关节软骨随时间变化的准确性：一项系统评价。
North Clin Istanb. 2022 Sep 5;9(4):414-418. doi: 10.14744/nci.2021.34270. eCollection 2022.
6
Biomechanics of the medial meniscus in the osteoarthritic knee joint.骨关节炎膝关节内侧半月板的生物力学
PeerJ. 2021 Nov 24;9:e12509. doi: 10.7717/peerj.12509. eCollection 2021.
7
Validation of joint space narrowing on plain radiographs and its relevance to partial knee arthroplasty.普通X线片上关节间隙变窄的验证及其与单髁膝关节置换术的相关性。
Bone Joint Res. 2021 Mar;10(3):173-187. doi: 10.1302/2046-3758.103.BJR-2020-0216.R1.
8
Analyzing Femorotibial Cartilage Thickness Using Anatomically Standardized Maps: Reproducibility and Reference Data.使用解剖学标准化图谱分析股胫关节软骨厚度：再现性和参考数据。
J Clin Med. 2021 Jan 26;10(3):461. doi: 10.3390/jcm10030461.
9
Learning-Based Cost Functions for 3-D and 4-D Multi-Surface Multi-Object Segmentation of Knee MRI: Data From the Osteoarthritis Initiative.基于学习的膝关节 MRI 三维和四维多表面多目标分割成本函数：来自骨关节炎倡议的数据。
IEEE Trans Med Imaging. 2018 May;37(5):1103-1113. doi: 10.1109/TMI.2017.2781541.
10
Cartilage can be thicker in advanced osteoarthritic knees: a tridimensional quantitative analysis of cartilage thickness at posterior aspect of femoral condyles.晚期骨关节炎膝关节的软骨可能更厚：股骨髁后侧软骨厚度的三维定量分析
Br J Radiol. 2018 Jul;91(1087):20170729. doi: 10.1259/bjr.20170729. Epub 2018 Apr 16.
本文引用的文献
1
Magnetic resonance imaging-based cartilage loss in painful contralateral knees with and without radiographic joint space narrowing: Data from the Osteoarthritis Initiative.基于磁共振成像的有或无影像学关节间隙变窄的疼痛对侧膝关节软骨损伤：来自骨关节炎倡议组织的数据。
Arthritis Rheum. 2009 Sep 15;61(9):1218-25. doi: 10.1002/art.24791.
2
Change in regional cartilage morphology and joint space width in osteoarthritis participants versus healthy controls: a multicentre study using 3.0 Tesla MRI and Lyon-Schuss radiography.在使用 3.0T MRI 和 Lyon-Schuss 射线照相的多中心研究中，骨关节炎患者与健康对照者的区域性软骨形态和关节间隙宽度变化。
Ann Rheum Dis. 2010 Jan;69(1):155-62. doi: 10.1136/ard.2008.099762.
3
Patterns of femorotibial cartilage loss in knees with neutral, varus, and valgus alignment.膝关节处于中立位、内翻位和外翻位时股骨胫骨软骨磨损模式。
Arthritis Rheum. 2008 Nov 15;59(11):1563-70. doi: 10.1002/art.24208.
4
Regional analysis of femorotibial cartilage loss in a subsample from the Osteoarthritis Initiative progression subcohort.骨关节炎倡议进展亚队列中一个子样本的股胫关节软骨损失区域分析。
Osteoarthritis Cartilage. 2009 Mar;17(3):291-7. doi: 10.1016/j.joca.2008.07.008. Epub 2008 Sep 11.
5
The osteoarthritis initiative: report on the design rationale for the magnetic resonance imaging protocol for the knee.骨关节炎倡议：膝关节磁共振成像方案的设计原理报告
Osteoarthritis Cartilage. 2008 Dec;16(12):1433-41. doi: 10.1016/j.joca.2008.06.016. Epub 2008 Sep 10.
6
Imaging in osteoarthritis.骨关节炎的影像学检查
Rheum Dis Clin North Am. 2008 Aug;34(3):645-87. doi: 10.1016/j.rdc.2008.04.006.
7
A technique for regional analysis of femorotibial cartilage thickness based on quantitative magnetic resonance imaging.一种基于定量磁共振成像的股骨胫软骨厚度区域分析技术。
IEEE Trans Med Imaging. 2008 Jun;27(6):737-44. doi: 10.1109/TMI.2007.907323.
8
One year change of knee cartilage morphology in the first release of participants from the Osteoarthritis Initiative progression subcohort: association with sex, body mass index, symptoms and radiographic osteoarthritis status.骨关节炎倡议进展亚队列首批参与者膝关节软骨形态的一年变化：与性别、体重指数、症状及影像学骨关节炎状态的关联
Ann Rheum Dis. 2009 May;68(5):674-9. doi: 10.1136/ard.2008.089904. Epub 2008 Jun 2.
9
Change in cartilage morphometry: a sample of the progression cohort of the Osteoarthritis Initiative.软骨形态测量学的变化：骨关节炎倡议进展队列的一个样本。
Ann Rheum Dis. 2009 Mar;68(3):349-56. doi: 10.1136/ard.2007.082107. Epub 2008 Apr 13.
Zotero 插件