Chondrometrics GmbH, Ainring, Germany.
Magn Reson Med. 2010 Mar;63(3):574-81. doi: 10.1002/mrm.22194.
The objective of this study was to develop a technique for analyzing spatial patterns of cartilage loss in the medial femoral condyle (MF), and to study MF cartilage loss in participants of the Osteoarthritis Initiative. Using a 0.7 mm sagittal double echo at steady state (DESS) sequence, 160 osteoarthritic knees from 80 participants with varying degrees of medial joint space narrowing were imaged at baseline and 1-year follow-up. MF cartilage was segmented and cartilage loss determined. Rate of change varied significantly (P = 0.0067) along the anterior-posterior extension of the MF, with the greatest changes (-45 microm, -2.7%) observed 30-60 degrees posterior to the trochlear notch. The rate was greater in the central MF after excluding peripheral aspects of the MF from analysis. Sensitivity to change was greatest at 45-75 degrees (standardized response mean = -0.32) but was minimally affected by medial-lateral trimming. In conclusion, the greatest sensitivity to change was achieved when analyzing the posterior aspect of the central, weight-bearing MF.
本研究旨在开发一种分析股骨内侧髁（MF）软骨丢失空间模式的技术，并研究 Osteoarthritis Initiative 参与者的 MF 软骨丢失情况。使用 0.7mm 矢状面双回波稳态（DESS）序列，对 80 名参与者的 160 个膝关节进行了基线和 1 年随访的成像，这些参与者的内侧关节间隙狭窄程度不同。对 MF 软骨进行分割并确定软骨丢失情况。MF 前-后延伸方向上的变化率差异有统计学意义（P = 0.0067），滑车切迹后 30-60 度处观察到最大变化（-45 微米，-2.7%）。排除 MF 外周部分后，MF 中央的变化率更大。在 45-75 度时，变化的敏感性最大（标准化反应均值=-0.32），但受内外修剪的影响最小。总之，当分析中央负重 MF 的后部时，可获得最大的变化敏感性。
