Tyler Kevin L, Selvaggi Suzanne M
Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, Madison, WI 53792, USA.
Diagn Cytopathol. 2011 Feb;39(2):101-4. doi: 10.1002/dc.21344.
Malignant cells of prostatic adenocarcinoma are rarely identified in urine. In most cases, this finding is associated with high stage tumor. Numerous descriptions of the morphology of prostatic adenocarcinoma have been reported using cytocentrifugated specimens. However, no specific morphologic description of prostatic adenocarcinoma in urine using liquid-based cytology has been previously described. Four cases of prostatic adenocarcinoma in urine using ThinPrep® liquid-based preparations were identified between 2002 and 2009 at the University of Wisconsin Hospital and Clinics. Three patients had either high stage tumor or metastatic disease at the time of diagnosis, while the remaining patient had low stage tumor. The morphology of each case was evaluated with specific attention to cell size, nuclear characteristics, nuclear to cytoplasmic ratio, and cytoplasmic characteristics. The resulting key features for prostatic adenocarcinoma in urine are clustering, increased nuclear to cytoplasmic ratio, and prominent nucleoli. Though typically the presence of prostatic adenocarcinoma in urine implies high stage tumor, cells of lower stage tumors may be seen in urine as well.
前列腺腺癌的恶性细胞在尿液中很少被发现。在大多数情况下，这一发现与高分期肿瘤有关。使用细胞离心标本对前列腺腺癌的形态学已有大量描述。然而，此前尚未有使用液基细胞学对尿液中前列腺腺癌进行特异性形态学描述的报道。2002年至2009年期间，在威斯康星大学医院及诊所发现了4例使用ThinPrep®液基制片的尿液中前列腺腺癌病例。3例患者在诊断时患有高分期肿瘤或转移性疾病，而其余1例患者患有低分期肿瘤。对每个病例的形态学进行了评估，特别关注细胞大小、核特征、核质比和细胞质特征。尿液中前列腺腺癌的关键特征是细胞聚集、核质比增加和核仁突出。虽然尿液中出现前列腺腺癌通常意味着高分期肿瘤，但低分期肿瘤的细胞也可能出现在尿液中。
