杰氏卫矛中的倍半萜类化合物作为有潜力的癌症化学预防剂。

Sesquiterpenes from Maytenus jelskii as potential cancer chemopreventive agents.

机构信息

Instituto Universitario de Bio-Organica Antonio Gonzalez, Universidad de La Laguna, Avenida Astrofisico Francisco Sanchez 2, La Laguna, 38206 Tenerife, Canary Islands, Spain.

出版信息

J Nat Prod. 2010 Feb 26;73(2):127-32. doi: 10.1021/np900476a.

DOI:10.1021/np900476a

PMID:20146433

Abstract

Seven new (1-4 and 7-9) sesquiterpenes with a dihydro-beta-agarofuran skeleton, along with four known compounds (5, 6, 10, and 11), have been isolated from the leaves of Maytenus jelskii. The structures of the new compounds were elucidated by means of spectroscopic data analysis, including 1D and 2D NMR techniques, and their absolute configurations were determined by circular dichroism and chemical correlations. The compounds have been tested for their inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). Compound 10 was found to be an effective antitumor-promoting agent and also showed a potent chemopreventive effect in an in vivo two-stage carcinogenesis model.

摘要

从长叶榆叶梅的叶子中分离得到了 7 个新的（1-4 和 7-9）倍半萜类化合物，具有二氢-β-agarofuran 骨架，以及 4 个已知化合物（5、6、10 和 11）。新化合物的结构通过光谱数据分析阐明，包括 1D 和 2D NMR 技术，其绝对构型通过圆二色性和化学相关性确定。这些化合物已被测试其对 12-O-十四烷酰佛波醇-13-醋酸酯（TPA）诱导的 Epstein-Barr 病毒早期抗原（EBV-EA）激活的抑制作用。发现化合物 10 是一种有效的抗肿瘤促进剂，并且在体内两阶段致癌模型中也显示出很强的化学预防作用。