南蛇藤中两个新的β-二氢沉香呋喃倍半萜及其抗增殖活性

Two New β-Dihydroagarofuran Sesquiterpenes from Celastrus orbiculatus Thunb and Their Anti-Proliferative Activity.

作者信息

Zhou Jingjing, Han Na, Lv Guanghui, Jia Lina, Liu Zhihui, Yin Jun

机构信息

Department of Pharmacognosy and Utilization Key Laboratory of Northeast Plant Materials, School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang 110016, China.

School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China.

出版信息

Molecules. 2017 Jun 9;22(6):948. doi: 10.3390/molecules22060948.

DOI:10.3390/molecules22060948

PMID:28598409

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6152708/

Abstract

Two new β-dihydroagarofuran-type sesquiterpenes (-) were isolated and identified from the fruit of Thunb, together with seventeen known compounds (-). The structures of the isolated new compounds were elucidated based on extensive spectroscopic analyses. The cytotoxic activities of the 19 sesquiterpenes on three cell lines, human acute promyelocytic leukemia HL-60, human leukemic K562, and human colon cancer HCT-116 cells, were evaluated in vitro Compound exhibited potent cytotoxic activity against HL-60, K562, and HCT116 cell lines with IC values of 3.61 μΜ, 17.13 μΜ and 10.15 μΜ, respectively, and the other compounds displayed moderate activity.

摘要

从吴茱萸果实中分离并鉴定出两种新的β-二氢agarofuran型倍半萜（-），以及十七种已知化合物（-）。基于广泛的光谱分析阐明了分离出的新化合物的结构。在体外评估了这19种倍半萜对三种细胞系，即人急性早幼粒细胞白血病HL-60、人白血病K562和人结肠癌HCT-116细胞的细胞毒性活性。化合物对HL-60、K562和HCT116细胞系表现出较强的细胞毒性活性，IC值分别为3.61μΜ、17.13μΜ和10.15μΜ，其他化合物表现出中等活性。