Konnov M V, Dobordzhginidze L M, Deev A D, Gratsianskiĭ N A
Kardiologiia. 2010;50(2):4-8.
To elucidate risk factors concordance between spouses in families of patients with "premature" coronary heart disease (CHD).
We examined 174 spouse pairs. There were 174 probands with "premature" (onset before 55 years) CHD aged 32-63 years and 174 their spouses aged 28-63 years. Among probands 18.4% had angina pectoris only and 81.6% had history of myocardial infarction. There were 10 patients with CHD among spouses (5.75%). Characteristics studied included alcohol consumption, tobacco smoking, education, body mass index (BMI), waist circumference (WC), heart rate, systolic and diastolic blood pressure (DBP), total, low and high density lipoprotein cholesterol, triglycerides (TG), apoproteins -I and B, lipoprotein (a), blood glucose and insulin, homeostasis model assessment-insulin resistance (HOMA IR), fibrinogen, activity of plasminogen activator inhibitor type 1. Concordance of variables of continuous and ordinal type was estimated by Spearmanis rank correlation coefficients adjusted for sex and age. Pairs were divided according to proband age (32-47 and 35-63 years) and spousal concordance for characteristics studied was evaluated separately in 2 groups distinguished by age of proband (probands 32-47, spouses 28-53 years, and probands 48-63, spouses 35-63 years) with presumably different duration of marriage/cohabitation.
Registered characteristics of spouses except apo -I correlated positively. Correlations between 9 characteristics were significant: education, insulin, HOMA IR, WC (R=0.608, 0.424, 0.421, 0.294; all p=0.0001), glucose (R=0.261; p=0.0007), TG and fibrinogen (both R=0.222; p=0.0036 and 0.0063, respectively), BMI and DBP (R=0.195 and 0.185, respectively; both p<0.016). All correlations were similar in groups of "younger" and "older" pairs with exception of PAI 1 activity (R = -0.035 and 0.320, respectively; p=0.042).
In families of patients with premature CHD we found various degree of spousal concordance for risk factors mostly those considered to be related to metabolic syndrome. Correlations between risk factors levels in groups with presumably different duration of marriage were similar suggesting that concordance was due to assortative mating.
阐明“早发性”冠心病（CHD）患者家庭中配偶间危险因素的一致性。
我们研究了174对配偶。有174名年龄在32 - 63岁的“早发性”（发病年龄在55岁之前）冠心病先证者以及174名年龄在28 - 63岁的他们的配偶。在先证者中，18.4%仅有心绞痛，81.6%有心肌梗死病史。配偶中有10名冠心病患者（5.75%）。研究的特征包括饮酒、吸烟、教育程度、体重指数（BMI）、腰围（WC）、心率、收缩压和舒张压（DBP）、总胆固醇、低密度和高密度脂蛋白胆固醇、甘油三酯（TG）、载脂蛋白 -I和B、脂蛋白（a）、血糖和胰岛素、稳态模型评估 - 胰岛素抵抗（HOMA IR）、纤维蛋白原、纤溶酶原激活物抑制剂1型的活性。连续型和有序型变量的一致性通过经性别和年龄调整的Spearman等级相关系数来估计。根据先证者年龄（32 - 47岁和48 - 63岁）将配偶对分组，并分别在按先证者年龄区分的两组（先证者32 - 47岁，配偶28 - 53岁；先证者48 - 63岁，配偶35 - 63岁）中评估研究特征的配偶一致性，这两组的婚姻/同居持续时间可能不同。
除载脂蛋白 -I外，配偶的登记特征呈正相关。9个特征之间的相关性显著：教育程度、胰岛素、HOMA IR、腰围（R = 0.608、0.424、0.421、0.294；均p = 0.0001）、血糖（R = 0.261；p = 0.0007）、甘油三酯和纤维蛋白原（两者R分别为0.222；p分别为0.0036和0.0063）、体重指数和舒张压（分别为R = 0.195和0.185；均p < 0.016）。除纤溶酶原激活物抑制剂1型活性外（分别为R = -0.035和0.320；p = 0.042），“年轻”和“年长”配偶对组中的所有相关性相似。
在早发性冠心病患者家庭中，我们发现配偶间危险因素存在不同程度的一致性，主要是那些被认为与代谢综合征相关的因素。在婚姻持续时间可能不同的组中，危险因素水平之间的相关性相似，这表明一致性是由于选型交配。
