Wang Zhancheng, Ji Wenhui, Song Yanqiu, Li Jin, Shen Yan, Zheng Hongchao, Ding Yueyou
Department of Cardiology, Shanghai Eighth People's Hospital, Shanghai, China.
Department of Internal medicine, Huajing Community Health Service Centre for Xuhui District, Shanghai, China.
J Clin Hypertens (Greenwich). 2017 Nov;19(11):1088-1095. doi: 10.1111/jch.13084. Epub 2017 Aug 30.
The authors performed a meta-analysis of observational studies to estimate the magnitude of spousal concordance for hypertension and to examine whether the concordance varied by important study methodological aspects. PubMed and Embase were searched up to June 2017 for cross-sectional, case-control, and cohort studies that investigated the concordance/association of hypertension between spouse pairs. A meta-analysis with random-effects models was performed by pooling adjusted odds ratios. Eight studies with a total number of 81 928 spouse pairs were eligible. The pooled results showed that spouses of individuals with hypertension had 41% (odds ratio, 1.41; 95% confidence interval, 1.21-1.64) increased odds of having hypertension themselves. The association applied to both men and women, and was not significantly different between studies with adjustment for body mass index and those without. The findings highlighted the importance of environmental factors in the development of hypertension.
作者进行了一项观察性研究的荟萃分析，以估计高血压配偶一致性的程度，并检验这种一致性是否因重要的研究方法学方面而有所不同。截至2017年6月，在PubMed和Embase数据库中检索了调查配偶间高血压一致性/关联性的横断面研究、病例对照研究和队列研究。通过汇总调整后的比值比，采用随机效应模型进行荟萃分析。八项研究共纳入81928对配偶，符合纳入标准。汇总结果显示，高血压患者的配偶患高血压的几率增加了41%（比值比，1.41；95%置信区间，1.21-1.64）。这种关联在男性和女性中均存在，并且在调整了体重指数的研究和未调整体重指数的研究之间没有显著差异。这些发现突出了环境因素在高血压发病中的重要性。
