Department of Microbiology and Immunology, University of Montreal, Montréal, QC, Canada.
FEMS Microbiol Lett. 2010 Apr;305(1):1-13. doi: 10.1111/j.1574-6968.2010.01904.x. Epub 2010 Jan 20.
Salmonella enterica represents a major human and animal pathogen. Many S. enterica genomes have been completed and many more genome sequencing projects are underway, constituting an excellent resource for comparative genome analysis studies leading to a better understanding of bacterial evolution and pathogenesis. Salmonella enterica serovar Typhimurium and Typhi are the best-characterized serovars, with the first being involved in localized gastroenteritis in many hosts and the latter causing a systemic human-specific disease. Here, we summarize the major genetic differences between the two different serovars. We detail the divergent repertoires of the virulence factors responsible for the pathogenesis of the organisms and that ultimately result in the distinct clinical outcomes of infection. This comparative genomic overview highlights hypotheses for future investigations on S. enterica pathogenesis and the basis of host specificity.
肠炎沙门氏菌是一种主要的人类和动物病原体。许多肠炎沙门氏菌基因组已经完成，更多的基因组测序项目正在进行中，这为比较基因组分析研究提供了极好的资源，有助于更好地理解细菌进化和发病机制。肠炎沙门氏菌血清型 Typhimurium 和 Typhi 是研究最为透彻的血清型，前者涉及许多宿主的局部胃肠炎，后者引起全身性、人类特有的疾病。在这里，我们总结了这两种不同血清型之间的主要遗传差异。我们详细描述了导致生物体发病机制的毒力因子的不同组成，最终导致感染的不同临床结果。这种比较基因组综述突出了肠炎沙门氏菌发病机制和宿主特异性基础的未来研究的假说。
