Lee J M, Kim S R, Yoo S J, Hong O K, Son H S, Chang S A
Department of Internal Medicine, The Catholic University of Korea, College of Medicine, Seoul, Republic of Korea.
J Int Med Res. 2009 Nov-Dec;37(6):1803-12. doi: 10.1177/147323000903700616.
This study was designed to investigate the relationship between adipokines in metabolic syndrome and insulin resistance. Sixty male and female subjects with or without metabolic syndrome and type 2 diabetes were included. The homeostasis model assessment of insulin resistance (HOMA-IR) was calculated. Compared with lean control subjects, patients with metabolic syndrome and type 2 diabetes had lower circulating levels of total adiponectin and high molecular weight (HMW) adiponectin, and higher levels of leptin and interleukin-6 (IL-6). Total and HMW adiponectin and the adiponectin/leptin (A/L) ratio were negatively correlated with HOMA-IR. After adjusting for age and sex, leptin, IL-6 and tumour necrosis factor-alpha (TNF-alpha) were positively correlated with HOMA-IR. After also adjusting for body mass index, HOMA-IR was found to be independently associated with leptin, A/L ratio and TNF-alpha levels. In conclusion, decreased total adiponectin and HMW adiponectin and increased leptin and IL-6 levels are characteristic of patients with metabolic syndrome and type 2 diabetes.
本研究旨在探讨代谢综合征中脂肪因子与胰岛素抵抗之间的关系。纳入了60名患有或未患有代谢综合征及2型糖尿病的男性和女性受试者。计算了胰岛素抵抗的稳态模型评估值（HOMA-IR）。与瘦的对照受试者相比，患有代谢综合征和2型糖尿病的患者循环中总脂联素和高分子量（HMW）脂联素水平较低，而瘦素和白细胞介素-6（IL-6）水平较高。总脂联素和HMW脂联素以及脂联素/瘦素（A/L）比值与HOMA-IR呈负相关。在调整年龄和性别后，瘦素、IL-6和肿瘤坏死因子-α（TNF-α）与HOMA-IR呈正相关。在进一步调整体重指数后，发现HOMA-IR与瘦素、A/L比值和TNF-α水平独立相关。总之，总脂联素和HMW脂联素降低以及瘦素和IL-6水平升高是代谢综合征和2型糖尿病患者的特征。
