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骨髓脂肪组织作为绝经后骨质疏松症的关键调节者——简要综述。

Bone Marrow Adipose Tissue as a Critical Regulator of Postmenopausal Osteoporosis - A Concise Review.

机构信息

Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.

Key Laboratory of Environment Correlative Dietology (Ministry of Education), Hubei Key Laboratory of Fruit Vegetable Processing Quality Control (Huazhong Agricultural University), School of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei, People's Republic of China.

出版信息

Clin Interv Aging. 2024 Jul 11;19:1259-1272. doi: 10.2147/CIA.S466446. eCollection 2024.

DOI:10.2147/CIA.S466446
PMID:39011312
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11249116/
Abstract

Postmenopausal osteoporosis (PMOP) is a major health problem affecting millions of women worldwide. PMOP patients are often accompanied by abnormal accumulation of bone marrow adipose tissue (BMAT). BMAT is a critical regulator of bone homeostasis, and an increasing BMAT volume is negatively associated with bone mass reduction or fracture. BMAT regulates bone metabolism via adipokines, cytokines and the immune system, but the specific mechanisms are largely unknown. This review emphasizes the impact of estrogen deficiency on bone homeostasis and BMAT expansion, and the mechanism by which BMAT regulates PMOP, providing a promising strategy for targeting BMAT in preventing and treating PMOP.

摘要

绝经后骨质疏松症（PMOP）是一个严重的健康问题，影响着全球数以百万计的女性。PMOP 患者常伴有骨髓脂肪组织（BMAT）的异常堆积。BMAT 是骨内稳态的关键调节剂，其体积的增加与骨量减少或骨折呈负相关。BMAT 通过脂肪因子、细胞因子和免疫系统来调节骨代谢，但具体机制尚不清楚。本综述强调了雌激素缺乏对骨内稳态和 BMAT 扩张的影响，以及 BMAT 调节 PMOP 的机制，为靶向 BMAT 预防和治疗 PMOP 提供了有前景的策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2185/11249116/a30bd0579b17/CIA-19-1259-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2185/11249116/728630874629/CIA-19-1259-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2185/11249116/2fa0703433ec/CIA-19-1259-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2185/11249116/9208b6809b37/CIA-19-1259-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2185/11249116/a30bd0579b17/CIA-19-1259-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2185/11249116/728630874629/CIA-19-1259-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2185/11249116/2fa0703433ec/CIA-19-1259-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2185/11249116/9208b6809b37/CIA-19-1259-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2185/11249116/a30bd0579b17/CIA-19-1259-g0004.jpg

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2
Circulating MicroRNA Expression, Vitamin D, and Hypercortisolism as Predictors of Osteoporosis in Elderly Postmenopausal Women.循环 microRNA 表达、维生素 D 和皮质醇过多症作为老年绝经后妇女骨质疏松症的预测因子。
Dis Markers. 2021 Dec 13;2021:3719919. doi: 10.1155/2021/3719919. eCollection 2021.
3
RANKL from bone marrow adipose lineage cells promotes osteoclast formation and bone loss.
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EMBO Rep. 2021 Jul 5;22(7):e52481. doi: 10.15252/embr.202152481. Epub 2021 Jun 13.
4
Senolytics improve bone forming potential of bone marrow mesenchymal stem cells from aged mice.衰老细胞溶解剂可提高老年小鼠骨髓间充质干细胞的骨形成潜力。
NPJ Regen Med. 2021 Jun 11;6(1):34. doi: 10.1038/s41536-021-00145-z.
5
Interaction between bone and immune cells: Implications for postmenopausal osteoporosis.骨骼与免疫细胞之间的相互作用：对绝经后骨质疏松症的影响。
Semin Cell Dev Biol. 2022 Mar;123:14-21. doi: 10.1016/j.semcdb.2021.05.014. Epub 2021 May 20.
6
Marrow adipogenic lineage precursor: A new cellular component of marrow adipose tissue.骨髓脂肪生成系前体细胞：骨髓脂肪组织的一个新的细胞成分。
Best Pract Res Clin Endocrinol Metab. 2021 Jul;35(4):101518. doi: 10.1016/j.beem.2021.101518. Epub 2021 Mar 15.
7
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Sensory nerves regulate mesenchymal stromal cell lineage commitment by tuning sympathetic tones.感觉神经通过调节交感神经张力来调节间充质基质细胞谱系的决定。
J Clin Invest. 2020 Jul 1;130(7):3483-3498. doi: 10.1172/JCI131554.