IRE1α-XBP1 通路对胎盘 CEA 家族基因表达的正向贡献。

Positive contribution of the IRE1alpha-XBP1 pathway to placental expression of CEA family genes.

机构信息

Iwawaki Initiative Research Unit, Advanced Science Institute, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.

出版信息

FEBS Lett. 2010 Mar 5;584(5):1066-70. doi: 10.1016/j.febslet.2010.02.012. Epub 2010 Feb 9.

DOI:10.1016/j.febslet.2010.02.012

PMID:20146926

Abstract

Inositol requiring enzyme-1alpha (IRE1alpha) is an ER-located transmembrane RNase whose activation leads to the production of the transcription factor X-box binding protein 1 (XBP1). Recently, we showed that the IRE1alpha-XBP1 pathway plays an essential role in the placenta. However, details of its function remain unclear. To address this point, we searched for IRE1alpha- or XBP1-regulated genes in the placenta, and identified the CEA family as a novel target of the IRE1alpha-XBP1 pathway. Moreover, PSG genes, which also belong to the CEA family, were up-regulated by XBP1. We have therefore identified a new aspect of the physiological function of the IRE1alpha-XBP1 pathway in the placenta.

摘要

肌醇需求酶 1α（IRE1α）是一种内质网定位的跨膜 RNA 酶，其激活导致转录因子 X 盒结合蛋白 1（XBP1）的产生。最近，我们表明 IRE1α-XBP1 途径在胎盘发挥重要作用。然而，其功能的细节仍不清楚。为了解决这一问题，我们在胎盘中搜索了 IRE1α 或 XBP1 调节的基因，并鉴定了 CEA 家族是 IRE1α-XBP1 途径的一个新靶标。此外，也属于 CEA 家族的 PSG 基因被 XBP1 上调。因此，我们在胎盘中鉴定了 IRE1α-XBP1 途径的生理功能的一个新方面。